糖皮质激素和盐皮质激素对人体胃液分泌的作用。

Glucocorticoid and mineralocorticoid actions on gastric secretion in man.

作者信息

Domschke W, Domschke S, Huber W, Demling L

出版信息

Acta Hepatogastroenterol (Stuttg). 1977 Feb;24(1):34-7.

Abstract

The effects of a 6-day course of treatment with a glucocorticoid (prednisolone, 1 g per day i.v.), a mineralocorticoid (9-alpha-fluorohydrocortisone, 0.3 mg per day orraly), or both the drugs on gastric secretion of acid, protein, pepsin, and N-acetylneuraminic acid (NANA) containing glycoproteins were investigated in 22 volunteers. None of the treatments produced any statistically significant changes in gastric secretion of aggressive factors, acid and pepsin. However, the output of protective NANA bound to glycoproteins was found to be decreased following prednisolone. The prednisolone effect was not prevented by 9-alpha-fluorhydrocortisone given concomitantly. Gastroduodenoscopy did not reveal any lesions attributable to drug adminstration.

摘要

在22名志愿者中，研究了糖皮质激素（泼尼松龙，每天静脉注射1克）、盐皮质激素（9-α-氟氢可的松，每天口服0.3毫克）或两种药物联合使用进行为期6天的治疗对胃酸、蛋白质、胃蛋白酶以及含N-乙酰神经氨酸（NANA）糖蛋白的胃分泌的影响。这些治疗均未使攻击因子、胃酸和胃蛋白酶的胃分泌产生任何具有统计学意义的变化。然而，发现泼尼松龙治疗后与糖蛋白结合的保护性NANA的分泌量减少。同时给予9-α-氟氢可的松并不能阻止泼尼松龙的这种作用。胃镜检查未发现任何可归因于药物给药的病变。