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心经和肺经的微循环特征：研究方案 临床试验（符合SPIRIT标准）

The microcirculatory characteristics of the heart and lung meridians: Study protocol clinical trial (SPIRIT Compliant).

作者信息

Hu Hantong, Jiang Yongliang, Li Xiaoyu, Lou Jiali, Zhang Yajun, He Xiaofen, Fang Junfan, Wu Yuanyuan, Shao Xiaomei, Fang Jianqiao

机构信息

The Third Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou City, Zhejiang Province.

Department of Neurobiology and Acupuncture Research, The Third Clinical Medical College, Zhejiang Chinese Medical University, Key Laboratory of Acupuncture and Neurology of Zhejiang Province, Hangzhou, China.

出版信息

Medicine (Baltimore). 2020 Apr;99(14):e19594. doi: 10.1097/MD.0000000000019594.

DOI:10.1097/MD.0000000000019594
PMID:32243379
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7220657/
Abstract

INTRODUCTION

The aim of the present study is to compare the microcirculatory difference of different meridians by using laser doppler flowmetry and investigate the specificity for the meridian-visceral association and site-to-site association between 2 specific meridians.

METHODS AND ANALYSIS

The Lung and Heart meridians are chosen as 2 specific studied meridians. 120 participants will be enrolled and divided into the healthy control group, chronic stable angina pectoris group and healthy intervention group. Laser doppler flowmetry will be used to assess the blood perfusion of the Heart and Lung meridians. The specificity for the meridian-visceral association will be investigated by comparing the microcirculatory difference between the Heart and Lung meridians in the healthy control group and chronic stable angina pectoris group. Besides, participants in the healthy intervention group will receive 2 sessions of moxibustion in the Heart meridian and Lung meridian, respectively, to explore the specificity for the site-to-site association on the body surface. Primary outcomes will be blood flow curve and blood perfusion units of relevant sites along the Heart and Lung meridians. Statistical analysis will be conducted by third party statisticians.

ETHICS AND DISSEMINATION

Ethics approval (approval No: ZSLL-KY-2019-001A-01) has been obtained from the Ethics Committee of the Third Affiliated Hospital of Zhejiang Chinese Medical University. The study findings will be disseminated through presentation at peer-reviewed medical journals.

TRIAL REGISTRATION

ClinicalTrials.gov NCT04244812.

摘要

引言

本研究旨在运用激光多普勒血流仪比较不同经络的微循环差异，并探究经络与脏腑关联以及两条特定经络之间部位与部位关联的特异性。

方法与分析

选取肺经和心经作为两条特定的研究经络。将招募120名参与者，分为健康对照组、慢性稳定型心绞痛组和健康干预组。运用激光多普勒血流仪评估心经和肺经的血液灌注情况。通过比较健康对照组和慢性稳定型心绞痛组心经与肺经的微循环差异，探究经络与脏腑关联的特异性。此外，健康干预组的参与者将分别接受心经和肺经的两次艾灸治疗，以探索体表部位与部位关联的特异性。主要结局指标将是心经和肺经沿线相关部位的血流曲线和血液灌注单位。将由第三方统计学家进行统计分析。

伦理与传播

已获得浙江中医药大学附属第三医院伦理委员会的伦理批准（批准号：ZSLL-KY-2019-001A-01）。研究结果将通过在同行评审医学期刊上发表进行传播。

试验注册

ClinicalTrials.gov NCT042448

12

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5769/7220657/a5db6de08bed/medi-99-e19594-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5769/7220657/69eed1ee0401/medi-99-e19594-g001.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5769/7220657/69eed1ee0401/medi-99-e19594-g001.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5769/7220657/a5db6de08bed/medi-99-e19594-g004.jpg

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