Su Li, Meng Ling, Chen Ran, Wu Weihua, Peng Bo, Man Lixin
Second Department of Cadre, Jinan Military General Hospital, Jinan, Shandong, China.
Forsch Komplementmed. 2016;23(1):16-21. doi: 10.1159/000443813. Epub 2016 Feb 15.
To evaluate the evidence available on the effects of acupuncture point (acupoint) application for asthma therapy in adults.
Six electronic databases were searched up to May 2014 to identify relevant studies. Randomized controlled trials, which assessed the effects of acupoint application for asthma treatment in adults, were included in our review. The methodological quality of eligible studies was assessed by the Cochrane Collaboration's tool. The standardized mean difference (SMD) and 95% confidence intervals (CI) of a random-effects model were calculated. The heterogeneity was assessed using I2 statistics.
Eight studies were included in our review. The aggregated results indicated that acupoint application improved forced expiratory volume in 1 second (FEV1) (SMD, 0.32; 95% CI 0.04-0.60; p = 0.03), FEV1/forced vital capacity (SMD, 0.89; 95% CI 0.70-1.09; p < 0.00001), interleukin (SMD, -0.26; 95% CI -0.50 to -0.01; p = 0.04) and immunoglobulin E (SMD, -0.49; 95% CI -0.83 to -0.16; p = 0.004) in patients with asthma, but not eosinophilic cation protein (SMD, -0.58; 95% CI -1.42 to 0.26; p = 0.18). There was no sufficient evidence for the follow-up effects of acupoint application for asthma therapy in adults.
Acupoint application may be a valid complementary and alternative therapy for asthma in adults. It contributes especially to improving pulmonary function and reducing the levels of interleukin and immunoglobulin E. However, more studies with longer follow-ups are warranted to confirm the current findings.
评估现有关于穴位敷贴治疗成人哮喘效果的证据。
检索截至2014年5月的六个电子数据库以识别相关研究。纳入评估穴位敷贴治疗成人哮喘效果的随机对照试验。采用Cochrane协作网工具评估合格研究的方法学质量。计算随机效应模型的标准化均数差（SMD）和95%置信区间（CI）。使用I²统计量评估异质性。
本综述纳入八项研究。汇总结果表明，穴位敷贴可改善哮喘患者的一秒用力呼气容积（FEV₁）（SMD，0.32；95%CI 0.04 - 0.60；p = 0.03）、FEV₁/用力肺活量（SMD，0.89；95%CI 0.70 - 1.09；p < 0.00001）、白细胞介素（SMD， - 0.26；95%CI - 0.50至 - 0.01；p = 0.04）和免疫球蛋白E（SMD， - 0.49；95%CI - 0.83至 - 0.16；p = 0.004），但对嗜酸性粒细胞阳离子蛋白无影响（SMD， - 0.58；95%CI - 1.42至0.26；p = 0.18）。没有足够证据证明穴位敷贴对成人哮喘治疗的后续效果。
穴位敷贴可能是成人哮喘有效的补充和替代疗法。它尤其有助于改善肺功能并降低白细胞介素和免疫球蛋白E水平。然而，需要更多随访时间更长的研究来证实目前的发现。
