5-氨基乙酰丙酸在间变性少突胶质细胞瘤（异柠檬酸脱氢酶突变型且1p/19q共缺失）中的假阳性
5-ALA False-Positive in Anaplastic Oligodendroglioma, IDH-mutant and 1p/19q-codeleted.
作者信息
La Rocca Giuseppe, Barresi Valeria, Sabatino Giovanni, Altieri Roberto, Ius Tamara, Olivi Alessandro, Mazzucchi Edoardo, Pignotti Fabrizio, Della Pepa Giuseppe Maria
机构信息
Institute of Neurosurgery, Fondazione Policlinico Universitario A. Gemelli Irccs, Catholic University, Rome, Italy, Department of Neurosurgery, Mater Olbia Hospital, Olbia, Italy.
Department of Diagnostics and Public Health, Section of Anatomical Pathology, University And Hospital Trust of Verona, Verona, Italy.
出版信息
Surg Technol Int. 2020 May 28;36:453-456.
Pr5-ALA has been well-established for use in intraoperative fluorescence-guided resection of malignant glioma. It is not as strongly supported for use with low-grade gliomas (LGG) because only a few of these, less than 20%, have visible porphyrin accumulation, which is useful for 5-ALA-guided surgery. We report here our experience with 5-ALA uptake in a case of suspected relapse of anaplastic oligodendroglioma, IDH-mutant and 1p/19q-codeleted.
5-氨基乙酰丙酸（5-ALA）已被广泛应用于术中荧光引导下切除恶性胶质瘤。对于低级别胶质瘤（LGG），其应用依据并不充分，因为这些肿瘤中只有不到20%会有可见的卟啉积聚，而卟啉积聚对5-ALA引导的手术很有用。我们在此报告1例异柠檬酸脱氢酶（IDH）突变且1p/19q共缺失的间变性少突胶质细胞瘤疑似复发病例中5-ALA摄取情况的经验。
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