Department of Medical Biotechnology and Nanotechnology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Department of Medical Biotechnology and Nanotechnology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran; Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran.
Eur J Pharmacol. 2020 Jun 15;877:173094. doi: 10.1016/j.ejphar.2020.173094. Epub 2020 Mar 31.
Cancer is a rising and major health issue around the world. The acquisition of resistance to chemotherapeutic drugs is a great obstacle for the effective treatment of nearly all cancers. Drug resistance is regulated by multiple factors and mechanisms including genetic mutations, abnormal expression of some cellular transporters such as multidrug resistance (MDR) transporters, changes in apoptotic pathways, cancer stem cells, tumor microenvironment, and noncoding RNAs (ncRNAs). Evidence clearly indicates a key role for sirtuins in several characteristics of cancer drug resistance. Recent studies demonstrated the crucial impact of some ncRNAs on sirtuins expression leading to modulation of chemotherapy resistance in cancers. In this review, we will focus on the current findings about the impacts of ncRNAs on the sirtuins pathway and their role in drug resistance of cancer.
癌症是全球范围内一个日益严重的主要健康问题。对化疗药物的耐药性的获得是几乎所有癌症有效治疗的巨大障碍。耐药性受多种因素和机制调节，包括遗传突变、某些细胞转运体如多药耐药（MDR）转运体的异常表达、凋亡途径的改变、癌症干细胞、肿瘤微环境和非编码 RNA（ncRNA）。有证据清楚地表明，沉默信息调节因子 2 相关酶（sirtuins）在癌症药物耐药性的几个特征中起关键作用。最近的研究表明，一些 ncRNA 对 sirtuins 表达的关键影响导致了癌症化疗耐药性的调节。在这篇综述中，我们将重点介绍 ncRNA 对 sirtuins 通路的影响及其在癌症耐药性中的作用的最新发现。
