Department of Biotechnology, College of Basic Medical Sciences, Dalian Medical University, 9 West Section, Lvshun Southern Road, Dalian, 116044, China.
Department of Hematology, Dalian Key Laboratory of Hematology, Diamond Bay Institute of Hematology, The Second Affiliated Hospital of Dalian Medical University, Dalian, 116027, China.
Mol Biol Rep. 2021 Apr;48(4):3579-3591. doi: 10.1007/s11033-021-06347-4. Epub 2021 Apr 20.
MicroRNAs (miRNAs) are a class of single-stranded noncoding and endogenous RNA molecules with a length of 18-25 nucleotides. Previous work has shown that miR-124-3p leads to malignant progression of cancer including cell apoptosis, migration, invasion, drug resistance, and also recovers neural function, affects adipogenic differentiation, facilitates wound healing through control of various target genes. miR-124-3p has been mainly previously characterized as a tumor suppressor regulating tumorigenesis and progression in several cancers, such as hepatocellular carcinoma (HCC), gastric cancer (GC), bladder cancer, ovarian cancer (OC), and leukemia, as a tumor promotor in breast cancer (BC), and it has been also widely studied in a variety of neurological diseases, like Parkinson's disease (PD), dementia and Alzheimer's disease (AD), and cardiovascular diseases, ulcerative colitis (UC), acute respiratory distress syndrome (ARDS). To lay the groundwork for future therapeutic strategies, in this review we mainly focus on the most recent years of literature on the functions of miR-124-3p in related major cancers, as well as its downstream target genes. Although current work as yet provides an incomplete picture, miR-124-3p is still worthy of more attention as a practical and effective clinical biomarker.
微小 RNA（miRNAs）是一类长度为 18-25 个核苷酸的单链非编码和内源性 RNA 分子。先前的研究表明，miR-124-3p 导致癌症的恶性进展，包括细胞凋亡、迁移、侵袭、耐药性，并恢复神经功能，影响脂肪生成分化，通过控制各种靶基因促进伤口愈合。miR-124-3p 主要以前被表征为肿瘤抑制因子，在多种癌症中调节肿瘤发生和进展，如肝细胞癌（HCC）、胃癌（GC）、膀胱癌、卵巢癌（OC）和白血病，作为乳腺癌（BC）中的肿瘤促进剂，也在多种神经疾病中广泛研究，如帕金森病（PD）、痴呆和阿尔茨海默病（AD）以及心血管疾病、溃疡性结肠炎（UC）、急性呼吸窘迫综合征（ARDS）。为未来的治疗策略奠定基础，在这篇综述中，我们主要关注近年来关于 miR-124-3p 在相关主要癌症中的功能及其下游靶基因的文献。尽管目前的工作还提供了一个不完整的画面，但 miR-124-3p 仍然作为一种实用有效的临床生物标志物值得更多关注。
