De Michele M, Amenta F
Dipartimento di Scienze Neurologiche, Università La Sapienza, Rome, Italy.
Clin Exp Hypertens A. 1988;10(6):1031-49. doi: 10.1080/07300077.1988.11878799.
The density and pattern of sympathetic nerve fibres in the kidneys of 16-week-old spontaneously hypertensive rats (SHR) and of control age-matched normotensive Wistar-Kyoto (WKY) rats were studied by catecholamine histofluorescence and acetylcholinesterase histochemical techniques. Varicose noradrenergic fibres primarily supply renal vasculature and were concentrated in small arteries and in afferent glomerular arterioles. The number and the density of these nerve fibres were increased in SHR. Acetylcholinesterase-positive nerve fibres were distributed to the renal vascular tree in the same way as the noradrenergic nerves and disappeared after chemical sympathectomy, suggesting their sympathetic nature. Acetylcholinesterase-positive perivascular nerve fibres were decreased in SHR. The possible significance of the two directional behaviour of sympathetic nerves (noradrenergic and acetylcholinesterase-positive) in the kidneys of SHR is discussed.
采用儿茶酚胺组织荧光法和乙酰胆碱酯酶组织化学技术，研究了16周龄自发性高血压大鼠（SHR）及年龄匹配的正常血压对照Wistar-Kyoto（WKY）大鼠肾脏中交感神经纤维的密度和分布模式。曲张的去甲肾上腺素能纤维主要供应肾血管系统，集中于小动脉和肾小球入球小动脉。这些神经纤维的数量和密度在SHR中增加。乙酰胆碱酯酶阳性神经纤维与去甲肾上腺素能神经以相同方式分布于肾血管树，化学性交感神经切除后消失，提示其交感神经性质。SHR中乙酰胆碱酯酶阳性血管周围神经纤维减少。讨论了SHR肾脏中交感神经（去甲肾上腺素能和乙酰胆碱酯酶阳性）双向变化的可能意义。
