Allen A M, Lewis S J, Verberne A J, Mendelsohn F A
University of Melbourne, Department of Medicine, Australia.
Clin Exp Hypertens A. 1988;10(6):1239-49. doi: 10.1080/07300077.1988.11878914.
Angiotensin II (Ang II) is known to attenuate the vagal component of the baroreflex at both central and peripheral cardiac sites. Ang II receptor binding sites occur in both the nucleus of the solitary tract (NTS), where they are associated with vagal afferent terminals, and in the dorsal motor nucleus of vagus. In this study we have examined the distribution of Ang II binding sites in the cell bodies of vagal afferents in the nodose ganglion, and investigated whether these receptors are transported in the vagus nerve. Dense Ang II receptor binding was observed over neuronal cell bodies in the nodose ganglion and, in streaks, in the vagus nerve. Vagal ligation distal to the nodose ganglion resulted in a marked accumulation of receptor binding sites, proximal to the ligature, with a moderate increase on the distal side. These results demonstrate that Ang II receptor binding sites occur in the nodose ganglion and are transported centrally in the vagus to be located on presynaptic terminals in the NTS and also peripherally where they may occur on terminals of the vagus.
已知血管紧张素II（Ang II）会在中枢和外周心脏部位减弱压力反射的迷走神经成分。Ang II受体结合位点存在于孤束核（NTS）中，与迷走神经传入终末相关，也存在于迷走神经背核中。在本研究中，我们检查了结状神经节中迷走神经传入神经元细胞体上Ang II结合位点的分布，并研究了这些受体是否在迷走神经中运输。在结状神经节的神经元细胞体上以及迷走神经中的条带上观察到密集的Ang II受体结合。在结状神经节远端进行迷走神经结扎导致结扎近端受体结合位点明显积聚，远端有适度增加。这些结果表明，Ang II受体结合位点存在于结状神经节中，并在迷走神经中向中枢运输，位于NTS的突触前终末上，在外周也可能存在于迷走神经的终末上。
