Kim Chul Min, Choi Hye Jin, Kim Gyu Man
Department of Mechanical Engineering, Korea Polytechnic University, Siheung-Si 15073, Korea.
School of Mechanical Engineering, Kyungpook National University, Daegu 41566, Korea.
Polymers (Basel). 2020 Apr 1;12(4):776. doi: 10.3390/polym12040776.
We present a 512-channel geometric droplet-splitting microfluidic device that involves the injection of a premixed emulsion for microsphere production. The presented microfluidic device was fabricated using conventional photolithography and polydimethylsiloxane casting. The fabricated microfluidic device consisted of 512 channels with 256 T-junctions in the last branch. Five hundred and twelve microdroplets with a narrow size distribution were produced from a single liquid droplet. The diameter and size distribution of prepared micro water droplets were 35.29 µm and 8.8% at 10 mL/h, respectively. Moreover, we attempted to prepare biocompatible microspheres for demonstrating the presented approach. The diameter and size distribution of the prepared poly (lactic-co-glycolic acid) microspheres were 6.56 µm and 8.66% at 10 mL/h, respectively. To improve the monodispersity of the microspheres, we designed an additional post array part in the 512-channel geometric droplet-splitting microfluidic device. The monodispersity of the microdroplets prepared with the microfluidic device combined with the post array part exhibited a significant improvement.
我们展示了一种512通道的几何液滴分裂微流控装置，该装置涉及注入预混合乳液以生产微球。所展示的微流控装置是使用传统光刻技术和聚二甲基硅氧烷浇铸法制造的。制造的微流控装置由512个通道组成，在最后一个分支中有256个T型接头。从单个液滴中产生了512个尺寸分布狭窄的微滴。在流速为10 mL/h时，制备的微水滴的直径和尺寸分布分别为35.29 µm和8.8%。此外，我们尝试制备生物相容性微球以证明所展示的方法。在流速为10 mL/h时，制备的聚（乳酸-乙醇酸）微球的直径和尺寸分布分别为6.56 µm和8.66%。为了提高微球的单分散性，我们在512通道几何液滴分裂微流控装置中设计了一个额外的后阵列部分。结合后阵列部分的微流控装置制备的微滴的单分散性有了显著提高。
