雌激素受体β（ERβ）对脂质稳态的调节——性别有影响吗？
Estrogen Receptor beta (ERβ) Regulation of Lipid Homeostasis-Does Sex Matter?
作者信息
Savva Christina, Korach-André Marion
机构信息
Department of Medicine, Metabolism Unit and KI/AZ Integrated Cardio Metabolic Center (ICMC), Metabolism and Karolinska Institutet at Karolinska University Hospital Huddinge, SE-141 86 Stockholm, Sweden.
Clinical Department of Endocrinology Diabetes, Karolinska University Hospital Huddinge, SE-141 86 Stockholm, Sweden.
出版信息
Metabolites. 2020 Mar 20;10(3):116. doi: 10.3390/metabo10030116.
Abstract
In this communication, we aim to summarize the role of estrogen receptor beta (ERβ) in lipid metabolism in the main metabolic organs with a special focus on sex differences. The action of ERβ is tissue-specific and acts in a sex-dependent manner, emphasizing the necessity of developing sex- and tissue-selective targeting drugs in the future.
摘要
在本通讯中，我们旨在总结雌激素受体β（ERβ）在主要代谢器官脂质代谢中的作用，特别关注性别差异。ERβ的作用具有组织特异性，且以性别依赖的方式发挥作用，这凸显了未来开发性别和组织选择性靶向药物的必要性。
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