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Effects of ERβ and ERα on OVX-induced changes in adiposity and insulin resistance.ERβ 和 ERα 对去卵巢诱导的肥胖和胰岛素抵抗变化的影响。
J Endocrinol. 2020 Apr;245(1):165-178. doi: 10.1530/JOE-19-0321.
2
Selective estrogen receptor (ER)β activation provokes a redistribution of fat mass and modifies hepatic triglyceride composition in obese male mice.选择性雌激素受体 (ER)β 激活会引起肥胖雄性小鼠脂肪量的重新分布，并改变肝甘油三酯的组成。
Mol Cell Endocrinol. 2020 Feb 15;502:110672. doi: 10.1016/j.mce.2019.110672. Epub 2019 Dec 5.
3
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4
Sex-specific lipid molecular signatures in obesity-associated metabolic dysfunctions revealed by lipidomic characterization in ob/ob mouse.肥胖相关代谢功能障碍中性别特异性脂质分子特征的脂质组学研究揭示了 ob/ob 小鼠。
Biol Sex Differ. 2019 Feb 26;10(1):11. doi: 10.1186/s13293-019-0225-y.
5
ERβ activation in obesity improves whole body metabolism via adipose tissue function and enhanced mitochondria biogenesis.肥胖状态下雌激素受体β的激活通过脂肪组织功能及增强线粒体生物合成改善全身代谢。
Mol Cell Endocrinol. 2019 Jan 5;479:147-158. doi: 10.1016/j.mce.2018.10.007. Epub 2018 Oct 17.
6
Estrogens and Body Weight Regulation in Men.男性的雌激素与体重调节。
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7
Estrogen receptor β selective agonist ameliorates liver cirrhosis in rats by inhibiting the activation and proliferation of hepatic stellate cells.雌激素受体 β 选择性激动剂通过抑制肝星状细胞的激活和增殖改善大鼠肝硬化。
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8
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9
An ERβ agonist induces browning of subcutaneous abdominal fat pad in obese female mice.一种 ERβ 激动剂可诱导肥胖雌性小鼠皮下腹部脂肪垫的棕色化。
Sci Rep. 2016 Dec 6;6:38579. doi: 10.1038/srep38579.
10
Pharmacologic activation of estrogen receptor β increases mitochondrial function, energy expenditure, and brown adipose tissue.雌激素受体β的药理学激活可增强线粒体功能、能量消耗以及棕色脂肪组织。
FASEB J. 2017 Jan;31(1):266-281. doi: 10.1096/fj.201600787RR. Epub 2016 Oct 12.

雌激素受体β（ERβ）对脂质稳态的调节——性别有影响吗？

Estrogen Receptor beta (ERβ) Regulation of Lipid Homeostasis-Does Sex Matter?

作者信息

Savva Christina, Korach-André Marion

机构信息

Department of Medicine, Metabolism Unit and KI/AZ Integrated Cardio Metabolic Center (ICMC), Metabolism and Karolinska Institutet at Karolinska University Hospital Huddinge, SE-141 86 Stockholm, Sweden.

Clinical Department of Endocrinology Diabetes, Karolinska University Hospital Huddinge, SE-141 86 Stockholm, Sweden.

出版信息

Metabolites. 2020 Mar 20;10(3):116. doi: 10.3390/metabo10030116.

DOI:10.3390/metabo10030116
PMID:32244965
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7143602/
Abstract

In this communication, we aim to summarize the role of estrogen receptor beta (ERβ) in lipid metabolism in the main metabolic organs with a special focus on sex differences. The action of ERβ is tissue-specific and acts in a sex-dependent manner, emphasizing the necessity of developing sex- and tissue-selective targeting drugs in the future.

摘要

在本通讯中，我们旨在总结雌激素受体β（ERβ）在主要代谢器官脂质代谢中的作用，特别关注性别差异。ERβ的作用具有组织特异性，且以性别依赖的方式发挥作用，这凸显了未来开发性别和组织选择性靶向药物的必要性。