Zhang Julia, Froelich Anna, Michniak-Kohn Bozena
Center for Dermal Research and Ernest Mario School of Pharmacy, Rutgers, The State University of New Jersey, 145 Bevier Road, Piscataway, NJ 08854, USA.
Chair and Department of Pharmaceutical Technology, Poznan University of Medical Sciences, Grunwaldzka 6, 60-780 Poznań, Poland.
Pharmaceutics. 2020 Mar 21;12(3):282. doi: 10.3390/pharmaceutics12030282.
The aim of this study is to develop, characterize and compare conventional liposome, deformable liposome (transfersome) and microemulsion formulations as potential topical delivery systems for meloxicam. Liposomes were characterized in terms of vesicle size, zeta potential and entrapment efficiency. For microemulsions, particle size, electrical conductivity and viscosity studies were performed to assess the structure of the investigated systems. An ex vivo skin permeation study has been conducted to compare these formulations. The dermal and transdermal delivery of meloxicam using these formulations can be a promising alternative to conventional oral delivery of non-steroidal anti-inflammatory drugs (NSAIDs) with enhanced local and systemic onset of action and reduced side effects.
本研究的目的是开发、表征和比较常规脂质体、可变形脂质体（传递体）和微乳剂配方，作为美洛昔康潜在的局部给药系统。脂质体通过囊泡大小、zeta电位和包封率进行表征。对于微乳剂，进行粒度、电导率和粘度研究以评估所研究体系的结构。已进行体外皮肤渗透研究以比较这些配方。使用这些配方进行美洛昔康的真皮和透皮给药可能是传统口服非甾体抗炎药（NSAIDs）给药的一个有前景的替代方案，具有增强的局部和全身起效作用以及减少的副作用。
