Bae Dong Sik, Koo Do Hoon, Kim Ji Eun, Cho Jae-Mahn, Park Jun-Ook
Department of Surgery, Haeundae Paik Hospital, Inje University College of Medicine, Busan 48108, Korea.
Department of Dermatology, CNP Skin Laser Clinic, Seoul 06267, Korea.
J Clin Med. 2020 Mar 21;9(3):868. doi: 10.3390/jcm9030868.
The persistence of neck scarring is a common concern among patients undergoing thyroidectomy. Botulinum toxin A (BTA (Botox)) has been shown to suppress scar enlargement at the incision site. The objective of this study was to evaluate the effect of intraoperative Botox administration on neck scarring after thyroidectomy. A prospective double-blind randomized clinical trial was performed in patients undergoing conventional thyroidectomy. Forty patients were randomly allocated to a Botox or a control group (both, = 20). The wound was closed after injection into the platysma muscle of 50 U of Botox diluted in 1 mL of normal saline or 1 mL of saline alone. Skin scars were assessed using the modified Stony Brook Scar Evaluation Scale (SBSES) and Manchester Scar Scale (MSS) at 1, 12, and 24 weeks postoperatively. The SBSES and MSS scores of the Botox group were significantly better than those of the control group ( = 0.034 and = 0.039). At 24 weeks postoperatively, the SBSES and MSS scores were significantly better in the Botox group ( = 0.006 and = 0.030). BTA injected into the incision site can suppress postoperative scar formation and thereby improve the cosmetic outcome.
甲状腺切除术后患者颈部瘢痕持续存在是一个常见的问题。A型肉毒杆菌毒素（BTA，商品名保妥适）已被证明可抑制切口部位瘢痕增大。本研究的目的是评估术中注射肉毒杆菌毒素对甲状腺切除术后颈部瘢痕形成的影响。对接受传统甲状腺切除术的患者进行了一项前瞻性双盲随机临床试验。40例患者被随机分为肉毒杆菌毒素组或对照组（每组n = 20）。在向颈阔肌注射用1 mL生理盐水稀释的50 U肉毒杆菌毒素或仅注射1 mL生理盐水后关闭伤口。术后1周、12周和24周使用改良的石溪瘢痕评估量表（SBSES）和曼彻斯特瘢痕量表（MSS）评估皮肤瘢痕。肉毒杆菌毒素组的SBSES和MSS评分显著优于对照组（P = 0.034和P = 0.039）。术后24周，肉毒杆菌毒素组的SBSES和MSS评分显著更好（P = 0.006和P = 0.030）。注射到切口部位的BTA可抑制术后瘢痕形成，从而改善美容效果。
