Laboratory of Kidney Physiology and Water-Ion Balance, I. M. Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, St. Petersburg, Russia.
Bull Exp Biol Med. 2020 Mar;168(5):634-636. doi: 10.1007/s10517-020-04768-y. Epub 2020 Apr 4.
In rats, intramuscular injection of oxytocin (0.25 nmol/100 g body weight) increased sodium excretion from 19±5 to 120±11 μmol/min. A significant correlation (p<0.001) was revealed between renal excretion of oxytocin and sodium ions. Under the action of oxytocin, natriuresis was characterized by diminished reabsorption of fluid in the proximal tubule of the nephron attested by elevated lithium clearance rate and from stimulation of V receptors in the cells of thick ascending loop of Henle. Pmp-Tyr(Me)-Phe-Gln-Asn-Cys-Pro-Arg-Gly-NH2, a V receptors antagonist, prevented the natriuretic effect of oxytocin.
在大鼠中，肌肉内注射催产素（0.25 nmol/100 g 体重）使钠排泄从 19±5 增加到 120±11 μmol/min。研究揭示了催产素和钠离子在肾脏排泄方面的显著相关性（p<0.001）。在催产素的作用下，利钠作用的特点是近端肾小管中液体重吸收减少，这可以通过升高锂清除率和刺激 Henle 粗升支细胞中的 V 受体来证明。Pmp-Tyr(Me)-Phe-Gln-Asn-Cys-Pro-Arg-Gly-NH2，一种 V 受体拮抗剂，可防止催产素的利钠作用。
