Russian Academy of Sciences, Tomsk National Research Medical Center, Tomsk, Russia.
Tomsk Regional Oncology Center, Tomsk, Russia.
Bull Exp Biol Med. 2020 Mar;168(5):677-680. doi: 10.1007/s10517-020-04779-9. Epub 2020 Apr 4.
We analyzed the content of β-catenin fractions and activity and content of proteasomes in the tissues of patients with non-small cells lung cancer. The content of β-catenin fractions was elevated and proteasome-dependent proteolysis in the tumor tissue was enhanced in comparison with the corresponding unchanged lung tissue. A negative regression relationship of caspase-like activity of proteasomes and a positive correlation between the content of proteasomes and both fractions of β-catenin were found. We hypothesize that proteasomes are involved in the degradation of β-catenin due to caspase-like activity.
我们分析了非小细胞肺癌患者组织中β-catenin 分数的含量和蛋白酶体的活性和含量。与相应的未改变的肺组织相比，肿瘤组织中β-catenin 分数的含量升高，蛋白酶体依赖性蛋白水解增强。发现蛋白酶体的半胱天冬酶样活性与β-catenin 两种分数之间存在负回归关系，而蛋白酶体的含量与β-catenin 两种分数之间存在正相关关系。我们假设蛋白酶体由于半胱天冬酶样活性而参与β-catenin 的降解。
