血管活性肠肽敏感的腺苷酸环化酶活性在肾单位中的分布。

Distribution of vasoactive intestinal peptide-sensitive adenylate cyclase activity along the nephron.

作者信息

Edwards R M

机构信息

Department of Pharmacology, Smith Kline and French Laboratories, Swedeland, PA 19406-0939.

出版信息

Eur J Pharmacol. 1988 Nov 22;157(2-3):227-30. doi: 10.1016/0014-2999(88)90387-1.

DOI:10.1016/0014-2999(88)90387-1

PMID:3224639

Abstract

The effect of vasoactive intestinal peptide (VIP) on adenylate cyclase activity in individual segments of the rabbit nephron was examined. VIP caused a significant increase in adenylate cyclase activity in the distal convoluted tubule and in the cortical and medullary portions of the collecting tubule. VIP also caused a concentration-dependent increase in adenylate cyclase activity in rat and dog collecting tubules. The results demonstrate that VIP has a direct stimulatory effect on tubular adenylate cyclase which may be involved in the increase in electrolyte excretion observed with VIP.

摘要

研究了血管活性肠肽（VIP）对兔肾单位各节段腺苷酸环化酶活性的影响。VIP可使远曲小管以及集合管皮质部和髓质部的腺苷酸环化酶活性显著升高。VIP还可使大鼠和犬集合管的腺苷酸环化酶活性呈浓度依赖性升高。结果表明，VIP对肾小管腺苷酸环化酶具有直接刺激作用，这可能与VIP引起的电解质排泄增加有关。