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血管活性肠肽对人肾腺苷酸环化酶的体外刺激作用。

Vasoactive intestinal peptide stimulation of human renal adenylate cyclase in vitro.

作者信息

Charlton B G, Neal D E, Simmons N L

机构信息

Department of Physiological Sciences, the Medical School, University of Newcastle upon Tyne, NE2 4HH.

出版信息

J Physiol. 1990 Apr;423:475-84. doi: 10.1113/jphysiol.1990.sp018034.

DOI:10.1113/jphysiol.1990.sp018034
PMID:2167366
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1189769/
Abstract
  1. A direct action of vasoactive intestinal peptide (VIP) upon human kidney was sought by measurement of renal adenylate cyclase in tissue homogenates and plasma membranes isolated from tissue samples excised for therapeutic reasons. 2. VIP (1 microM) produced a mean stimulation of adenylate cyclase activity of 3.5-fold compared to basal values in cortical plasma membranes; comparative stimulations of 2.8-fold and 27.3-fold were obtained with 1 microM-glucagon and 1 microM-h(1-34) parathyroid hormone respectively. 3. Half-maximal stimulation of human renal cortical plasma membrane adenylate cyclase was observed with a mean value of 35 nM-VIP. 4. The stimulation of renal adenylate cyclase by VIP appeared to be specific because stimulation by glucagon was additive to that obtained with VIP, and the VIP receptor antagonist (4 Cl-D-Phe6, Leu17)-VIP inhibited the VIP-dependent stimulation of adenylate cyclase activity.
摘要
  1. 通过测量从因治疗原因切除的组织样本中分离出的组织匀浆和质膜中的肾腺苷酸环化酶，来探寻血管活性肠肽（VIP）对人肾脏的直接作用。2. 与皮质质膜中的基础值相比，1微摩尔VIP使腺苷酸环化酶活性平均刺激了3.5倍；1微摩尔胰高血糖素和1微摩尔人甲状旁腺激素（1 - 34）分别产生了2.8倍和27.3倍的相对刺激。3. 观察到人肾皮质质膜腺苷酸环化酶的半数最大刺激时，VIP的平均值为35纳摩尔。4. VIP对肾腺苷酸环化酶的刺激似乎具有特异性，因为胰高血糖素的刺激与VIP的刺激具有加和性，并且VIP受体拮抗剂（4 - 氯 - D - 苯丙氨酸6，亮氨酸17）-VIP抑制了依赖VIP的腺苷酸环化酶活性刺激。

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Vasoactive intestinal peptide stimulation of human renal adenylate cyclase in vitro.血管活性肠肽对人肾腺苷酸环化酶的体外刺激作用。
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本文引用的文献

1
Adenylate cyclase responsiveness to hormones in various portions of the human nephron.人肾单位各部分中腺苷酸环化酶对激素的反应性。
J Clin Invest. 1980 Feb;65(2):439-48. doi: 10.1172/JCI109687.
2
Vasoactive intestinal polypeptide-immunoreactive nerves in the kidney.肾脏中血管活性肠肽免疫反应性神经
Neurosci Lett. 1983 Dec 30;43(2-3):263-9. doi: 10.1016/0304-3940(83)90199-4.
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Effects of vasoactive intestinal polypeptide on renal function in man.血管活性肠肽对人体肾功能的影响。
J Physiol. 1983 Dec;345:469-75. doi: 10.1113/jphysiol.1983.sp014989.
4
Effects of vasoactive intestinal polypeptide (VIP) on renal function and plasma renin activity in the conscious rabbit.血管活性肠肽（VIP）对清醒家兔肾功能及血浆肾素活性的影响。
J Physiol. 1983 Nov;344:379-88. doi: 10.1113/jphysiol.1983.sp014946.
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Preferential binding of vasoactive intestinal polypeptide to basolateral membrane of rat and rabbit enterocytes.血管活性肠肽与大鼠和兔肠上皮细胞基底外侧膜的优先结合。
J Clin Invest. 1983 Jan;71(1):27-35. doi: 10.1172/jci110748.
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Polypeptide with broad biological activity: isolation from small intestine.具有广泛生物活性的多肽：从小肠中分离得到。
Science. 1970 Sep 18;169(3951):1217-8. doi: 10.1126/science.169.3951.1217.
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Biological activities of synthetic peptides corresponding to fragments of and to the entire sequence of the vasoactive intestinal peptide.与血管活性肠肽片段及整个序列对应的合成肽的生物活性。
Proc Natl Acad Sci U S A. 1973 Feb;70(2):382-4. doi: 10.1073/pnas.70.2.382.
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Vasoactive intestinal peptide in the regulation of renin secretion.
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Vasoactive intestinal peptide: a direct renal natriuretic substance.
Clin Sci (Lond). 1987 Feb;72(2):195-200. doi: 10.1042/cs0720195.
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Vasoactive intestinal peptide-immunoreactive nerves in the rat kidney.大鼠肾脏中血管活性肠肽免疫反应性神经
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