Bingmann D, Speckmann E J, Baker R E, Ruijter J, de Jong B M
Poliklinik für zahnärztliche Chirurgie der Universität, Mainz, Federal Republic of Germany.
Exp Brain Res. 1988;72(2):439-42. doi: 10.1007/BF00250266.
Effects of the organic calcium antagonists verapamil and flunarizine on pentylenetetrazol induced paroxysmal depolarizations were tested in organotypic neocortical explants taken from neonatal rats. In these in vitro experiments the papaverin derivative verapamil depressed, and finally abolished, epileptic discharges in all cases. The piperazine derivative flunarizine, however, which is known to suppress epileptic discharges in hippocampal CA3 neurons (Bingmann and Speckmann 1986), showed no significant antiepileptic effects in the explanted neocortical neurons. Thus, the present findings may indicate that the suppressive action of flunarizine on the generation of paroxysmal depolarizations is restricted to distinct populations of neurons.
在取自新生大鼠的器官型新皮质外植体中测试了有机钙拮抗剂维拉帕米和氟桂利嗪对戊四氮诱导的阵发性去极化的影响。在这些体外实验中，罂粟碱衍生物维拉帕米在所有情况下均抑制并最终消除了癫痫放电。然而，已知能抑制海马CA3神经元癫痫放电的哌嗪衍生物氟桂利嗪，在移植的新皮质神经元中未显示出明显的抗癫痫作用。因此，目前的研究结果可能表明，氟桂利嗪对阵发性去极化产生的抑制作用仅限于不同的神经元群体。
