维拉帕米和氟桂利嗪对癫痫患者和原发性非癫痫患者新皮质组织中荷包牡丹碱和低镁诱导的癫痫样活动的影响。

The effects of verapamil and flunarizine on epileptiform activity induced by bicuculline and low Mg2+ in neocortical tissue of epileptic and primary non-epileptic patients.

作者信息

Straub H, Köhling R, Lüke A, Fauteck J D, Speckmann E J, Moskopp D, Wassmann H, Tuxhorn I, Wolf P, Pannek H, Oppel F

机构信息

Institut für Physiologie, Universität Münster, Germany.

出版信息

Brain Res. 1996 Sep 16;733(2):307-11. doi: 10.1016/0006-8993(96)00802-5.

DOI:10.1016/0006-8993(96)00802-5

PMID:8891316

Abstract

In human neocortical slices the specific L-type calcium channel blocker verapamil had been shown to be antiepileptic in the low Mg(2+)-model of epilepsy. The present investigation demonstrated: (1) verapamil exerted also an antiepileptic effect on epileptiform field potentials (EFP) induced by the GABAA-antagonist bicuculline. (2) The unspecific calcium channel modulator flunarizine, which in contrast to verapamil penetrates the blood-brain barrier, depressed EFP in the low Mg(2+)-model and in the bicuculline model. (3) There was no significant difference in the antiepileptic efficacy of verapamil and flunarizine in epileptic (epilepsy surgery) and primary non-epileptic (tumor surgery) neocortical slices.

摘要

在人类新皮质切片中，特定的L型钙通道阻滞剂维拉帕米已被证明在低镁癫痫模型中具有抗癫痫作用。本研究表明：（1）维拉帕米对GABAA拮抗剂荷包牡丹碱诱导的癫痫样场电位（EFP）也有抗癫痫作用。（2）与维拉帕米不同，非特异性钙通道调节剂氟桂利嗪可穿透血脑屏障，在低镁模型和荷包牡丹碱模型中均可抑制EFP。（3）在癫痫（癫痫手术）和原发性非癫痫（肿瘤手术）新皮质切片中，维拉帕米和氟桂利嗪的抗癫痫疗效无显著差异。