Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.
Cellular and Molecular Research Center, Cellular and Molecular Medicine Institute, Urmia University of Medical Sciences, Urmia, Iran.
J Biomed Mater Res A. 2020 May;108(7):1444-1458. doi: 10.1002/jbm.a.36912. Epub 2020 Apr 15.
Nanotechnology empowered localized cancer chemotherapy has indicated a promising performance for targeting and controlled release of anticancer agents over a period of time to eliminate local-regional recurrence of cancers and also to improve the tissue regeneration during/after treatment. Electrospun nanofiber-based implantable drug-delivery systems have been established as one of the most effective approaches for localized cancer treatment, allowing the on-site delivery of anticancer agents and reducing systemic toxicities and side effects to normal cells. The present review aimed to summarize the latest cutting-edge research on applications of electrospun-based systems for local chemotherapy. Meantime, in vitro and in vivo studies conducted using various anticancer agents along with the capability of electrospun nanofibers for combinatorial/synergistic chemotherapy as well as existing challenges and the potential dramatic advances in applying this pioneering approach for clinical transition in localized treatments of cancer is also discussed.
纳米技术赋能的局部癌症化疗在靶向和控制抗癌药物释放方面表现出了很大的潜力，它可以在一段时间内消除癌症的局部和区域性复发，还可以改善治疗期间/之后的组织再生。基于静电纺丝的纳米纤维植入式药物输送系统已被确立为局部癌症治疗的最有效方法之一，它可以实现在现场输送抗癌药物，并降低全身毒性和对正常细胞的副作用。本综述旨在总结静电纺丝系统在局部化疗中的最新尖端应用研究。同时，还讨论了使用各种抗癌药物进行的体外和体内研究，以及静电纺纳米纤维在联合/协同化疗方面的能力，以及在将这种开创性方法应用于癌症局部治疗的临床转化中存在的挑战和潜在的巨大进展。
