大鼠中重铬酸钠肾毒性的年龄依赖性差异。

Age dependent differences in sodium dichromate nephrotoxicity in rats.

作者信息

Appenroth D, Bräunlich H

机构信息

Institute of Pharmacology and Toxicology, Friedrich Schiller University, Jena, DDR.

出版信息

Exp Pathol. 1988;33(3):179-85. doi: 10.1016/s0232-1513(88)80065-3.

DOI:10.1016/s0232-1513(88)80065-3

PMID:3224679

Abstract

Investigations were performed on 10- and 55-day-old female Wistar rats. 1 or 2 mg sodium dichromate/100 g b. m. were administered subcutaneously. Urine was collected for 1 hour at different times after dichromate injection. Total urinary protein as well as some protein fractions (high and low molecular weight proteins as well as albumin) were determined. In adult rats dose dependence of nephrotoxicity was found concerning the extent and duration of renal damage. Separation of proteins gave an insight into the location of injury. At the beginning and in the recovery phase preferentially tubular damage was found. The peak of damage is characterized by additional glomerular disturbances. Young rats are much less susceptible to dichromate than adult rats are. Possible reasons are discussed.

摘要

对10日龄和55日龄的雌性Wistar大鼠进行了研究。皮下注射重铬酸钠，剂量为1或2毫克/100克体重。在注射重铬酸盐后的不同时间收集1小时尿液。测定总尿蛋白以及一些蛋白组分（高分子量和低分子量蛋白以及白蛋白）。在成年大鼠中，发现肾毒性存在剂量依赖性，涉及肾损伤的程度和持续时间。蛋白质分离有助于了解损伤的位置。在开始阶段和恢复阶段，优先发现肾小管损伤。损伤高峰的特征是伴有肾小球紊乱。幼鼠比重铬酸盐对成年大鼠的敏感性低得多。文中讨论了可能的原因。