甲吡酮和苯巴比妥对发育中大鼠重铬酸钠肾毒性的影响。
Influence of metyrapone and phenobarbital on sodium dichromate nephrotoxicity in developing rats.
作者信息
Appenroth D, Gambaryan S, Friese K H, Bräunlich H
机构信息
Institute of Pharmacology and Toxicology, Friedrich Schiller University Jena, GDR.
出版信息
J Appl Toxicol. 1990 Jun;10(3):227-32. doi: 10.1002/jat.2550100314.
After the administration of equal doses of sodium dichromate, chromium concentrations in the kidney were lower in young than in adult rats. To test the age-dependent sensitivity to the nephrotoxicity of dichromate, young and adult rats were given doses to achieve identical chromium concentrations in the kidney. At equal renal concentrations, young rats had less functional and morphological damage than adult rats. As phenobarbital treatment in young rats enhanced the symptoms of nephrotoxicity and metyrapone treatment in adult rats decreased the symptoms of nephrotoxicity, age-dependent differences in chromate nephrotoxicity may be linked to an increase in the enzymatic reduction of Cr(VI) with age.
给予等量重铬酸钠后，幼龄大鼠肾脏中的铬浓度低于成年大鼠。为了测试年龄依赖性对重铬酸盐肾毒性的敏感性，给幼龄和成年大鼠给予能使肾脏中铬浓度相同的剂量。在肾脏浓度相等时，幼龄大鼠的功能和形态损伤比成年大鼠少。由于幼龄大鼠接受苯巴比妥治疗会加重肾毒性症状，成年大鼠接受美替拉酮治疗会减轻肾毒性症状，铬酸盐肾毒性的年龄依赖性差异可能与随着年龄增长Cr(VI)酶促还原增加有关。
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