Department of Cancer Epidemiology and Prevention Research, Alberta Health Services, Canada; Forzani & MacPhail Colon Cancer Screening Centre, Alberta Health Services, Canada; Department of Community Health Sciences, Cumming School of Medicine, University of Calgary, Canada.
Department of Cancer Epidemiology and Prevention Research, Alberta Health Services, Canada.
Prev Med. 2020 Jun;135:106072. doi: 10.1016/j.ypmed.2020.106072. Epub 2020 Apr 1.
There is suggestive evidence for the role of vitamin D in the development of colorectal cancer (CRC). Due to high latitudes in Canada, many Canadians are vitamin D deficient throughout winter. In this analysis, we examined the association between vitamin D supplement use and high-risk adenomatous polyps (HRAPs). The study population was drawn from the biorepository at the Forzani & MacPhail Colon Cancer Screening Centre (CCSC) in Calgary. Individuals enrolled between 2013 and 2016 between the age of 50 and 74 years (n = 1409) were included. When examining the association between any supplemental vitamin D use and HRAPs, a protective effect is observed with an OR of 0.57 (95% CI: 0.33-0.96). Similarly, meeting the recommended daily intake (RDI) of vitamin D (600 IU) is protective against HRAPs with an OR of 0.78 (95% CI: 0.62-0.99). This study suggests that adequate vitamin D supplementation reduces the occurrence of colorectal polyps in high-latitude locations.
有证据表明维生素 D 对结直肠癌（CRC）的发展起作用。由于加拿大纬度较高，许多加拿大人在整个冬季都缺乏维生素 D。在这项分析中，我们研究了维生素 D 补充剂使用与高危腺瘤性息肉（HRAP）之间的关系。研究人群来自卡尔加里福扎尼和麦克费尔结肠癌筛查中心（CCSC）的生物库。2013 年至 2016 年间，年龄在 50 至 74 岁之间的 1409 人参与了研究。当我们研究任何维生素 D 补充剂使用与 HRAPs 之间的关联时，观察到具有保护作用的比值比（OR）为 0.57（95%CI：0.33-0.96）。同样，每日推荐摄入量（RDI）的维生素 D（600IU）对 HRAPs 也具有保护作用，比值比（OR）为 0.78（95%CI：0.62-0.99）。这项研究表明，在高纬度地区，充足的维生素 D 补充剂可减少结直肠息肉的发生。
