高脂肪饮食摄入会对啮齿动物脊髓挫伤后的免疫血液学参数产生负面影响。
Immuno-hematologic parameters following rodent spinal cord contusion are negatively influenced by high-fat diet consumption.
机构信息
Cancer Center and Research Institute, University of Mississippi Medical Center, Jackson, MS 39216, United States of America.
Department of Neurobiology and Anatomical Sciences, University of Mississippi Medical Center, Jackson, MS 39216, United States of America.
出版信息
J Neuroimmunol. 2020 Jun 15;343:577226. doi: 10.1016/j.jneuroim.2020.577226. Epub 2020 Mar 27.
Abstract
Spinal cord injury (SCI) results in perturbations to the immune system leading to increased infection susceptibility. In parallel, the consumption of high-fat diets (HFD) leads to a chronic inflammation in circulation and body tissues. We investigated the impact of 16 weeks of HFD on chronically-injured rats. SCI rats under both chow and HFD showed peripheral leukocyte changes that include reduced percentages of total, helper and cytotoxic T, and natural killer cells. Expression of immune-related genes in the spleen and thymus reflected the impact of both chronic injury and diet. Changes to the immune system following SCI are adversely impacted by HFD consumption.
摘要
脊髓损伤 (SCI) 会导致免疫系统紊乱，从而增加感染的易感性。与此同时，高脂肪饮食 (HFD) 的摄入会导致循环和身体组织的慢性炎症。我们研究了 16 周 HFD 对慢性损伤大鼠的影响。无论是在普通饮食还是 HFD 下，SCI 大鼠的外周白细胞都会发生变化，包括总白细胞、辅助性 T 细胞和细胞毒性 T 细胞以及自然杀伤细胞的比例降低。脾和胸腺中免疫相关基因的表达反映了慢性损伤和饮食的双重影响。SCI 后免疫系统的变化会因 HFD 的摄入而受到不利影响。
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