Oil Crops Research Institute of the Chinese Academy of Agricultural Sciences, Oil Crops and Lipids Process Technology National & Local Joint Engineering Laboratory, Hubei Key Laboratory of Lipid Chemistry and Nutrition, Key Laboratory of Oilseeds Processing, Ministry of Agriculture and Rural Affairs, No. 2 Xudong 2nd Road, Wuhan 430062, China.
Oil Crops Research Institute of the Chinese Academy of Agricultural Sciences, Oil Crops and Lipids Process Technology National & Local Joint Engineering Laboratory, Hubei Key Laboratory of Lipid Chemistry and Nutrition, Key Laboratory of Oilseeds Processing, Ministry of Agriculture and Rural Affairs, No. 2 Xudong 2nd Road, Wuhan 430062, China.
Food Res Int. 2020 May;131:108994. doi: 10.1016/j.foodres.2020.108994. Epub 2020 Jan 10.
Flaxseed (Linum usitatissimum L.) is known as healthy food for its anti-obesity and lipid modulating properties. However, the effects of flaxseed polysaccharide (FSP) on metabolic syndrome (MetS) and gut microbiota are still poorly understood. Here, we investigated the effects of FSP on lipid metabolism and gut microbiota in high-fat-diet-fed mice. FSP effectively reduced the serum fasting glucose, total triglyceride and total cholesterol levels. FSP consumption adipose accumulation impacted the gut microbiome at different taxonomic levels by increasing the proportions of beneficial Akkermansia and Bifidobacterium and decreasing the disease or obesity associated Oscillospira and Odoribacteraceae. These changes were highly correlated with the regulation of expression levels of lipid metabolism involved genes in the liver. The restoration of total SCFAs, especially propionate and butyrate might be an important strategy for mitigating HFD induced metabolic disorders. These findings suggest that FSP may use as a prebiotic for preventing MetS by modulating the gut microbiota.
亚麻籽（Linum usitatissimum L.）因其具有抗肥胖和调节脂质的特性而被称为健康食品。然而，亚麻籽多糖（FSP）对代谢综合征（MetS）和肠道微生物群的影响仍知之甚少。在这里，我们研究了 FSP 对高脂肪饮食喂养的小鼠脂质代谢和肠道微生物群的影响。FSP 能有效降低血清空腹血糖、总甘油三酯和总胆固醇水平。FSP 可通过增加有益的阿克曼氏菌和双歧杆菌的比例，减少与疾病或肥胖相关的 Oscillospira 和 Odoribacteraceae 的比例，从而在不同的分类水平上影响肠道微生物群。这些变化与肝脏中涉及脂质代谢的基因表达水平的调节高度相关。恢复总 SCFAs，特别是丙酸和丁酸可能是缓解 HFD 引起的代谢紊乱的重要策略。这些发现表明，FSP 可通过调节肠道微生物群作为一种益生元来预防 MetS。
