Institute-associated Research Group: Cell Adhesion and Cell Polarity, Institute of Medical Biochemistry, ZMBE, University of Münster, Germany.
Division of Cell Structure, National Institute for Physiological Sciences, Okazaki, Aichi, Japan; Department of Physiological Sciences, School of Life Science, SOKENDAI (The Graduate University for Advanced Studies), Okazaki, Aichi, Japan.
Biochim Biophys Acta Biomembr. 2020 Sep 1;1862(9):183299. doi: 10.1016/j.bbamem.2020.183299. Epub 2020 Apr 2.
Junctional adhesion molecules (JAMs) comprise a small subfamily of the immunoglobulin superfamily of adhesion receptors with a multitude of physiological functions in vertebrate development and homeostasis. Several members of the JAM family localize at tight junctions of epithelial and endothelial cells where they interact with PDZ domain-containing scaffolding proteins. For some JAM family members, molecular mechanisms have been elaborated through which they regulate cell-cell contact maturation and tight junction formation. For other members of this family our knowledge on their role in barrier-forming epithelia is still fragmentary. Here, we review our current understanding of the contribution of JAM family proteins to the barrier function of epithelial and endothelial cells with a major focus on epithelial tight junctions.
连接黏附分子（JAMs）属于免疫球蛋白超家族黏附受体的一个小亚家族，在脊椎动物的发育和稳态中具有多种生理功能。JAM 家族的几个成员定位于上皮细胞和内皮细胞的紧密连接处，在该处它们与含有 PDZ 结构域的支架蛋白相互作用。对于一些 JAM 家族成员，已经阐述了其调节细胞-细胞接触成熟和紧密连接形成的分子机制。对于该家族的其他成员，我们对其在上皮形成屏障的上皮细胞中的作用的了解仍然很零散。在这里，我们综述了目前对 JAM 家族蛋白对上皮细胞和内皮细胞屏障功能的贡献的认识，主要集中在上皮细胞紧密连接上。
