Department of Neurology, University Clinical Centre Tuzla, Bosnia and Herzegovina.
Medical Faculty, University of Tuzla, Bosnia and Herzegovina.
Med Hypotheses. 2020 Jun;139:109683. doi: 10.1016/j.mehy.2020.109683. Epub 2020 Mar 19.
Hyperkalemic periodic paralysis (hyperkalemic PP) is a rare muscle disease that has onset in infancy or early childhood and is manifested by transient episodes of paralysis. In this case we presented a young male adult with attacks of weakness, after commencement of the antiepileptic drug - Carbamazepine. We hypothesize that Carbamazepine, as voltage-gate sodium channel blocker, aggravated the symptoms of hyperkalemic PP, as sodium channelopathies, in this young-male-patient, trough influence on membrane depolarization.
高钾周期性麻痹（hyperkalemic PP）是一种罕见的肌肉疾病，通常在婴儿期或幼儿期发病，表现为短暂的瘫痪发作。在本病例中，我们报告了一位年轻成年男性在开始使用抗癫痫药物卡马西平后出现无力发作的情况。我们推测卡马西平作为电压门控钠离子通道阻滞剂，通过对膜去极化的低谷影响，加重了这位年轻男性患者的高钾周期性麻痹的症状，因为钠离子通道病就是这样。
