School of Nutrition, Chung Shan Medical University, 110, Sec. 1, Jianguo North Road, Taichung City-40201, Taiwan, Republic of China.
Department of Chinese Medicine, Taichung Hospital Ministry of Health and Welfare, Taichung-40301, Taiwan, Republic of China.
Food Funct. 2020 Apr 30;11(4):2792-2804. doi: 10.1039/d0fo00357c.
In recent times many researchers are expressing immense interest in nutraceuticals and functional foods for combating various diseases or abnormal conditions, especially against hypertension (HT). Persistent HT is medically referred to as chronic high blood pressure (BP) and considered to be one of the major risk factors for the deadliest diseases including cardiovascular disease (CVD) and cerebrovascular diseases. Hence HT poses a serious socio-economic burden worldwide, particularly to developing countries. The current treatment strategy for HT includes standard anti-hypertensive drugs, which are associated with many adverse effects and lower drug adherence rates. Therefore, an alternative or complementary natural therapy (functional foods or nutraceuticals or dietary supplements) would be the alternate choice along with a modified lifestyle pattern that might help to manage or combat HT and its related complications. During this review, the author would like to shed light on the basic science behind HT including pathophysiology and the impact of dietary salt on HT and the impact of various functional foods or nutraceuticals against HT in humans (meta-analysis and systemic review). This contribution gives a better idea (public health perspective) for choosing the best functional foods/nutraceuticals for the prevention, management or delaying the onset of HT and its associated conditions along with modified lifestyle patterns and standard anti-hypertensive drugs.
近年来，许多研究人员对营养保健品和功能性食品表现出浓厚的兴趣，希望利用它们来对抗各种疾病或异常情况，尤其是高血压（HT）。持续的 HT 在医学上被称为慢性高血压（BP），被认为是包括心血管疾病（CVD）和脑血管疾病在内的最致命疾病的主要危险因素之一。因此，HT 在全球范围内造成了严重的社会经济负担，尤其是对发展中国家而言。目前 HT 的治疗策略包括标准的降压药物，但这些药物与许多不良反应和较低的药物依从性有关。因此，除了改变生活方式外，选择替代或补充天然疗法（功能性食品、营养保健品或膳食补充剂）可能有助于控制或对抗 HT 及其相关并发症。在本次综述中，作者希望阐明 HT 背后的基础科学，包括病理生理学以及膳食盐对 HT 的影响，以及各种功能性食品或营养保健品对人类 HT 的影响（荟萃分析和系统评价）。这一研究为选择最佳的功能性食品/营养保健品以预防、管理或延缓 HT 及其相关疾病的发生提供了更好的思路（从公共卫生角度出发），同时也考虑了改变生活方式和标准降压药物的作用。
