Department of Internal Medicine, Section on Cardiovascular Medicine, Wake Forest School of Medicine, 1 Medical Center Boulevard, Winston-Salem, NC, 27157, USA.
Department of Pathology, Section on Comparative Medicine, Wake Forest School of Medicine, 1 Medical Center Boulevard, Winston-Salem, NC, 27157, USA.
J Cardiovasc Transl Res. 2020 Jun;13(3):367-376. doi: 10.1007/s12265-020-09981-8. Epub 2020 Apr 4.
Animal models of chemotherapy-induced cardiotoxicity have been instrumental in understanding the underlying mechanisms of the disease. The use of cardiac magnetic resonance (CMR) imaging and nuclear magnetic resonance (NMR) imaging in preclinical models allows the non-invasive study of subclinical pathophysiological processes that influence cardiac function and establish imaging parameters that can be adopted into clinical practice to predict cardiovascular outcomes. Given the rising population of cancer survivors and the current lack of effective therapies for the management of cardiotoxicity, research combining clinically relevant animal models and non-invasive cardiac imaging remains essential to improve methods to monitor, predict, and treat cardiovascular adverse events. This comprehensive review summarizes the lessons learned from animal models of cardiotoxicity employing CMR and tissue characterization techniques and discusses the ongoing challenges and hopes for the future.
动物模型在研究化疗诱导的心脏毒性的发病机制方面发挥了重要作用。心脏磁共振（CMR）成像和核磁共振（NMR）成像在临床前模型中的应用允许对影响心脏功能的亚临床病理生理过程进行非侵入性研究，并建立可应用于临床实践的成像参数，以预测心血管结局。鉴于癌症幸存者人数的增加和目前缺乏有效的心脏毒性管理疗法，结合临床相关动物模型和非侵入性心脏成像的研究仍然至关重要，有助于改善监测、预测和治疗心血管不良事件的方法。这篇综述总结了应用 CMR 和组织特征技术的心脏毒性动物模型的经验教训，并讨论了目前的挑战和未来的希望。
