Altai Regional Oncology Center, Barnaul, Russia.
Institute of Molecular Pathology and Pathomorphology, Federal Research Center for Fundamental and Translational Medicine, Novosibirsk, Russia.
Bull Exp Biol Med. 2020 Mar;168(5):688-693. doi: 10.1007/s10517-020-04781-1. Epub 2020 Apr 4.
We studied the correlations of the expression of Ki-67 proliferation marker and localization of heat shock protein Hsp70 in tumor cells of papillary thyroid cancer with some clinical and morphological parameters and a 10-year survival prognosis. High variability of the proliferative activity (by Ki-67 index) of tumor cells was revealed. It was found that Hsp70 protein has different localization in tumor cells: cytoplasmic, nuclear, nucleolar, and mixed. Nuclear translocation of the Hsp70 protein correlated with the stage of the process and the prognosis of the disease, but did not correlate with sex, tumor size, capsule invasion, and lymph node metastasis. Ki-67 index of tumor cells correlated with sex, stage of the process, size of tumor formation and prognosis, but did not correlated with age, invasion into the capsule and metastasis to the lymph nodes. Depending on the variants of Hsp70 and Ki-67 co-expression, three molecular types of papillary thyroid cancer can be distinguished: favorable, intermediate, and poor prognosis.
我们研究了甲状腺乳头状癌肿瘤细胞中 Ki-67 增殖标志物的表达与热休克蛋白 Hsp70 的定位与某些临床和形态学参数及 10 年生存预后的相关性。结果显示肿瘤细胞的增殖活性（Ki-67 指数）存在高度变异性。还发现 Hsp70 蛋白在肿瘤细胞中有不同的定位：细胞质、核质、核仁质和混合质。Hsp70 蛋白的核转位与病程的阶段和疾病的预后相关，但与性别、肿瘤大小、包膜侵犯和淋巴结转移无关。肿瘤细胞的 Ki-67 指数与性别、病程阶段、肿瘤形成的大小和预后相关，但与年龄、包膜侵犯和淋巴结转移无关。根据 Hsp70 和 Ki-67 共表达的变异体，可以将甲状腺乳头状癌分为三种分子类型：预后良好、预后中等和预后不良。
