Seo Young Joon, Brown Daniel
Department of Otorhinolaryngology, Yonsei University Wonju College of Medicine, Wonju, Korea.
Research Institute of Hearing Enhancement, Yonsei University Wonju College of Medicine, Wonju, Korea.
J Audiol Otol. 2020 Apr;24(2):53-60. doi: 10.7874/jao.2020.00115. Epub 2020 Mar 31.
Several novel animal models that represent the pathophysiological process of endolymphatic hydrops (ELH) of Meniere's disease (MD) have been developed. Animal models are important to identify and characterize the pathophysiology of ELH and to corroborate molecular and genetic findings in humans. This review of the current animal models will be useful in understanding the pathophysiology of and developing proper treatments for MD. Surgical animal models will be replaced by medication-induced animal models. Study models previously developed in guinea pigs will be developed in several smaller animals for ease of conducting molecular analysis. In this review, we provided updated resources including our previous studies regarding the current and desirable animal models for MD.
已经开发出了几种代表梅尼埃病（MD）内淋巴积水（ELH）病理生理过程的新型动物模型。动物模型对于识别和表征ELH的病理生理学以及证实人类的分子和遗传研究结果非常重要。对当前动物模型的这一综述将有助于理解MD的病理生理学并开发适当的治疗方法。手术动物模型将被药物诱导的动物模型所取代。以前在豚鼠身上开发的研究模型将在几种较小的动物身上开发，以便于进行分子分析。在这篇综述中，我们提供了最新的资源，包括我们之前关于MD当前和理想动物模型的研究。
