Zhang Mengjie, Wang Changhong, Zhang Xinxin, Song Huiling, Li Yan
Department of Children, Adolescents and Women Health, College of Public Health, Zhengzhou University, Zhengzhou, Henan, China.
Department of Psychiatry, The Second Affiliated Hospital of Xinxiang Medical University, Xinxiang, Henan, China.
Int J Environ Health Res. 2022 Jan;32(1):207-219. doi: 10.1080/09603123.2020.1745764. Epub 2020 Apr 4.
Recent studies have reached mixed conclusions regarding the association between exposure to air pollutants and attention-deficit hyperactivity disorder (ADHD). We performed systematic review and meta-analysis to determine whether air pollutants were risk factors for the development of ADHD in children. We systematically searched databases for all relevant studies up to 2 July 2019. Together, the studies indicated that exposure to PAHs (risk ratio (RR): 0.98, 95% confidence interval (CI): 0.82-1.17), NOx (RR: 1.04, 95% CI: 0.94-1.15), and PM (RR: 1.11, 95% CI: 0.93-1.33) did not have any material relationship with an increased risk of ADHD. Heterogeneity of study data was low (: 2.7%, = 0.409) for studies examining PAHs, but was substantial for NOx and PM (: 68.4%, = 0.007 and : 60.1%, = 0.014, respectively). However, these results should be interpreted with caution since the number of epidemiological studies investigating this issue were limited.
最近的研究对于接触空气污染物与注意力缺陷多动障碍（ADHD）之间的关联得出了不一致的结论。我们进行了系统评价和荟萃分析，以确定空气污染物是否为儿童患ADHD的风险因素。我们系统检索了截至2019年7月2日的所有相关研究数据库。综合来看，这些研究表明，接触多环芳烃（风险比（RR）：0.98，95%置信区间（CI）：0.82 - 1.17）、氮氧化物（RR：1.04，95% CI：0.94 - 1.15）和颗粒物（RR：1.11，95% CI：0.93 - 1.33）与ADHD风险增加没有任何实质性关联。对于研究多环芳烃的研究，研究数据的异质性较低（I²：2.7%，P = 0.409）但对于氮氧化物和颗粒物来说异质性很大（分别为I²：68.4%，P = 0.007和I²：60.1%，P = 0.014）。然而，由于调查此问题的流行病学研究数量有限，这些结果应谨慎解读。
