Fondazione Policlinico Universitario A, Gemelli IRCCS, Rome, Italy.
IRCCS Fondazione Don Carlo Gnocchi, Florence, Italy.
Muscle Nerve. 2020 Jun;61(6):773-778. doi: 10.1002/mus.26880. Epub 2020 Apr 24.
This was a multicenter, double-blind, randomized clinical trial to investigate the efficacy of electrical stimulation of denervated muscle (ESDM) on recovery of patients with peripheral nerve injuries.
We enrolled 38 patients with traumatic peripheral nerve injuries with axonal damage and clinical impairment of two muscles, who were randomly treated with real or sham electrical stimulation (ES). Clinical and neurophysiological examinations were performed before treatment, at the end of treatment, and 3 mo posttreatment, by the same physician who was blinded to the ES allocation.
All patients improved but there was no significant beneficial effect of ESDM compared with sham treatment.
This study failed to demonstrate the efficacy of ESDM for peripheral nerve injuries. However, given the large number of variables related to ES and the heterogeneity in disease etiologies and clinical manifestations, future studies on homogeneous populations using different stimulation protocols may be useful.
这是一项多中心、双盲、随机临床试验，旨在研究去神经肌肉电刺激（ESDM）对外周神经损伤患者康复的疗效。
我们招募了 38 名外伤性周围神经损伤伴轴索损伤和两块肌肉临床功能障碍的患者，他们被随机接受真电刺激或假电刺激（ES）治疗。在治疗前、治疗结束时和治疗后 3 个月，由对 ES 分配不知情的同一位医生进行临床和神经生理学检查。
所有患者均有改善，但 ESDM 治疗与假治疗相比无显著益处。
本研究未能证明 ESDM 对外周神经损伤有效。然而，鉴于与 ES 相关的大量变量以及疾病病因和临床表现的异质性，未来在使用不同刺激方案的同质人群中进行的研究可能会有所帮助。
