Kazan Federal University, A.M. Butlerov Chemical Institute, 420008 Kremlevskaya, 18, Kazan, Russian Federation.
Institute of Fundamental Medicine and Biology, Kazan Federal University, 420008 Kremlevskaya, 18, Kazan, Russian Federation.
Org Biomol Chem. 2020 Jun 10;18(22):4210-4216. doi: 10.1039/d0ob00411a.
Novel water-soluble, deca-substituted pillar[5]arenes containing thiasulfate and thiacarboxylate fragments were synthesized and characterized. UV-vis, 2D 1H-1H NOESY and DOSY NMR spectroscopy revealed the ability of pillar[5]arenes containing thiasulfate fragments to form an inclusion complex with cholecalciferol (vitamin D3) in a 1 : 2 ratio (lg Kass = 2.2). Using DLS and SEM it was found that upon concentration and/or evaporation of the solvent, the supramolecular polymer (pillar[5]arene/vitamin D3 (1 : 2)) forms a porous material with an average wall diameter of 53 nm. It was shown that the supramolecular polymer is stable during photolysis by UV radiation (k1 = 1.7 × 10-5 s-1).
合成并表征了新型水溶性、十取代的含硫代硫酸盐和硫代羧酸片段的杯[5]芳烃。紫外可见光谱、二维 1H-1H NOESY 和 DOSY NMR 光谱表明，含硫代硫酸盐片段的杯[5]芳烃能够与胆钙化醇（维生素 D3）以 1:2 的比例形成包合物（lg Kass = 2.2）。通过 DLS 和 SEM 发现，在溶剂浓缩和/或蒸发时，超分子聚合物（杯[5]芳烃/维生素 D3（1:2））形成具有平均壁直径为 53nm 的多孔材料。结果表明，在紫外辐射（k1 = 1.7×10-5 s-1）下，超分子聚合物通过光解是稳定的。
