含莫西沙星的自修复硫醇化柱[5]芳烃薄膜可抑制细菌生物膜的形成。
Self-Healing Thiolated Pillar[5]arene Films Containing Moxifloxacin Suppress the Development of Bacterial Biofilms.
作者信息
Shurpik Dmitriy N, Aleksandrova Yulia I, Mostovaya Olga A, Nazmutdinova Viktoriya A, Tazieva Regina E, Murzakhanov Fadis F, Gafurov Marat R, Zelenikhin Pavel V, Subakaeva Evgenia V, Sokolova Evgenia A, Gerasimov Alexander V, Gorodov Vadim V, Islamov Daut R, Cragg Peter J, Stoikov Ivan I
机构信息
A.M.Butlerov Chemical Institute, Kazan Federal University, Kremlevskaya, 18, 420008 Kazan, Russia.
Institute of Physics, Kazan Federal University, Kremlevskaya, 18, 420008 Kazan, Russia.
出版信息
Nanomaterials (Basel). 2022 May 9;12(9):1604. doi: 10.3390/nano12091604.
Polymer self-healing films containing fragments of pillar[5]arene were obtained for the first time using thiol/disulfide redox cross-linking. These films were characterized by thermogravimetric analysis and differential scanning calorimetry, FTIR spectroscopy, and electron microscopy. The films demonstrated the ability to self-heal through the action of atmospheric oxygen. Using UV-vis, 2D 1H-1H NOESY, and DOSY NMR spectroscopy, the pillar[5]arene was shown to form complexes with the antimicrobial drug moxifloxacin in a 2:1 composition (logK11 = 2.14 and logK12 = 6.20). Films containing moxifloxacin effectively reduced and biofilms formation on adhesive surfaces.
首次通过硫醇/二硫化物氧化还原交联制备了含有柱[5]芳烃片段的聚合物自愈合薄膜。这些薄膜通过热重分析、差示扫描量热法、傅里叶变换红外光谱和电子显微镜进行了表征。这些薄膜表现出通过大气氧气作用进行自愈合的能力。利用紫外可见光谱、二维氢-氢核欧沃豪斯效应光谱和扩散排序光谱，柱[5]芳烃被证明能与抗菌药物莫西沙星以2:1的组成形成配合物（logK11 = 2.14和logK12 = 6.20）。含有莫西沙星的薄膜能有效减少黏附表面上的生物膜形成。
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