School of Medicine, University College Cork, Cork, Ireland.
INFANT Research Centre, Cork, Ireland; School of Public Health, University College Cork, Cork, Ireland.
J Affect Disord. 2020 May 15;269:94-100. doi: 10.1016/j.jad.2020.03.027. Epub 2020 Mar 10.
To investigate the relationship between prenatal maternal alcohol consumption and the risk of attention deficit hyperactivity disorder (ADHD), the strengths and difficulties questionnaire (SDQ) score and abnormal hyperactivity score in seven-year-old children.
This study is a retrospective analysis of the Millennium Cohort Study (MCS). Questionnaires were used to gather data on gestational alcohol consumption when children were 9 months old and neurodevelopmental outcomes in offspring at 7 years of age (N = 13,004). Alcohol consumption was classified into never, light, moderate and heavy. Crude and adjusted logistic regression models were used for data analysis.
The total number of women who reported drinking alcohol in pregnancy (the light, moderate and heavy drinking group) was 3916 (30.1%). No significant association was found between light, moderate or heavy gestational alcohol consumption and ADHD (adjusted odds ratio [aOR] for light = 0.80, 95% confidence interval [CI] = [0.53,1.22], aOR for moderate = 0.83, [0.40, 1.74]; aOR for heavy = 1.27, [0.54, 2.98]); for abnormal SDQ score (aOR for light = 0.94, [0.78,1.13], aOR for moderate = 0.70, [0.49,1.00]; aOR for heavy = 1.08, [0.70, 1.66]); for abnormal Hyperactivity score (aOR for light = 1.02, [0.89,1.17]; aOR for moderate = 1.05, [0.82, 1.34]; aOR for heavy = 0.90, [0.62, 1.32]), in offspring.
Light, moderate or heavy antenatal alcohol consumption was not associated with an increased susceptibility to ADHD or behavioural outcomes in this study. However, due to the limited number of cases we cannot rule out an increased risk of ADHD in relation to heavy alcohol consumption.
研究产前母亲饮酒与注意缺陷多动障碍（ADHD）风险、7 岁儿童的困难问题问卷（SDQ）评分和异常多动评分之间的关系。
本研究是对千禧年队列研究（MCS）的回顾性分析。当儿童 9 个月大时，使用问卷收集关于妊娠期间饮酒的数据，以及 7 岁时子女的神经发育结果（N=13004）。饮酒分为从不、轻度、中度和重度。使用未校正和校正的逻辑回归模型进行数据分析。
报告怀孕期间饮酒的女性总数（轻度、中度和重度饮酒组）为 3916 人（30.1%）。轻、中、重度妊娠期饮酒与 ADHD 之间无显著关联（轻度饮酒的校正比值比[aOR]为 0.80，95%置信区间[CI]为[0.53,1.22]，中度饮酒的 aOR 为 0.83，[0.40,1.74]；重度饮酒的 aOR 为 1.27，[0.54,2.98]）；异常 SDQ 评分（轻度饮酒的 aOR 为 0.94，[0.78,1.13]，中度饮酒的 aOR 为 0.70，[0.49,1.00]；重度饮酒的 aOR 为 1.08，[0.70,1.66]）；异常多动评分（轻度饮酒的 aOR 为 1.02，[0.89,1.17]；中度饮酒的 aOR 为 1.05，[0.82,1.34]；重度饮酒的 aOR 为 0.90，[0.62,1.32]）。
在本研究中，轻度、中度或重度产前饮酒与 ADHD 易感性或行为结果增加无关。然而，由于病例数量有限，我们不能排除与重度饮酒相关的 ADHD 风险增加。
