Department of Ophthalmology, University of Paris Est, Creteil, France.
Ophthalmology Center for Imaging and Laser, Paris, France; and.
Retina. 2021 Jan 1;41(1):82-92. doi: 10.1097/IAE.0000000000002806.
To report intraretinal hyperreflective lines related to various macular conditions.
All cases were imaged with color photographs, autofluorescence images, and spectral-domain optical coherence tomography, some with fluorescein and/or indocyanine green angiography. Demographic data, imaging, course and outcome were retrospectively analyzed.
Forty-nine eyes of 43 patients (16 men and 27 women) were included. Hyperreflective vertical lines (38 eyes) or curvilinear lines along the Henle fiber layer (11 eyes) were present in association with various macular conditions: adult vitelliform dystrophy or pattern dystrophy (24 eyes) frequently associated with an epiretinal membrane (six eyes) and/or thick choroid (nine eyes), age-related maculopathy or macular degeneration (nine eyes), partial resorption of subretinal or intraretinal hemorrhages (five eyes), idiopathic macular microhole (two eyes), vitreomacular traction (three eyes), multiple evanescent white dot syndrome (three eyes), fundus flavimaculatus (two eyes), and pachychoroid pigment epitheliopathy (one eye). The lines fully vanished in cases of hemorrhages, multiple evanescent white dot syndrome or resolution of vitreomacular traction, but usually persisted with gradual thinning in the other conditions.
The present series showed that intraretinal hyperreflective lines could occur in various inflammatory, degenerative, or tractional conditions. They could reflect a previously unrecognized reaction to various photoreceptor, Müller cell, and/or retinal pigment epithelium damage.
报告与各种黄斑病变相关的视网膜内高反射线。
所有病例均行彩色照相、自发荧光图像和频域光相干断层扫描检查，部分行荧光素和（或）吲哚青绿血管造影。回顾性分析患者的人口统计学资料、影像学表现、病程和转归。
共纳入 43 例患者的 49 只眼（男 16 例，女 27 例）。49 只眼中 38 只眼存在垂直高反射线，11 只眼存在沿 Henle 纤维层的曲线状高反射线，这些眼均与各种黄斑病变相关：成人型卵黄样变性或图案状变性（24 只眼）常伴有视网膜前膜（6 只眼）和（或）脉络膜增厚（9 只眼）、年龄相关性黄斑病变或黄斑变性（9 只眼）、视网膜下或视网膜内出血部分吸收（5 只眼）、特发性黄斑微裂孔（2 只眼）、玻璃体黄斑牵引（3 只眼）、多发性一过性白点综合征（3 只眼）、眼底黄色斑点症（2 只眼）和厚脉络膜色素上皮病变（1 只眼）。出血、多发性一过性白点综合征或玻璃体黄斑牵引缓解后，高反射线完全消失，但在其他病变中，高反射线通常会逐渐变薄而持续存在。
本研究系列表明，视网膜内高反射线可发生于各种炎症、变性或牵引性病变中。这些高反射线可能反映了各种光感受器、Müller 细胞和/或视网膜色素上皮损伤后的一种先前未被认识的反应。
