Department of Chemistry, Graduate School of Science, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan.
Org Lett. 2020 Apr 17;22(8):3171-3175. doi: 10.1021/acs.orglett.0c00932. Epub 2020 Apr 6.
In the presence of a catalytic amount of either Zn(acac) or bis(2,2,6,6-tetramethyl-3,5-heptanedionato)zinc(II) (Zn(TMHD)), primary, secondary, and tertiary alcohol substituents on a wide range of substrates, including acyclic and cyclic structures, carbohydrates, steroids, and amino acids, reacted with dimethyl phosphite to afford the corresponding H-phosphonate diesters in high to excellent yields.
在催化量的 Zn(acac)或双(2,2,6,6-四甲基-3,5-庚二酮)锌(II) (Zn(TMHD))的存在下，包括脂环和环结构、碳水化合物、甾体和氨基酸在内的各种底物上的伯、仲和叔醇取代基与亚磷酸二甲酯反应，以高至优异的收率得到相应的 H-膦酸二酯。
