Zhao Depeng, Yuan Ye, Chan Albert S C, Wang Rui
State Key Laboratory of Applied Organic Chemistry and Institute of Biochemistry and Molecular Biology, School of Life Sciences, Lanzhou University, Lanzhou 730000, China.
Chemistry. 2009;15(12):2738-41. doi: 10.1002/chem.200802688.
Zinc benefits: The first catalytic asymmetric phospha-Michael addition of enones has been developed. Under mild reaction conditions, the gamma-oxo phosphonates could be obtained in high yields (up to 99%) with excellent enantioselectivities (93-99% ee; see scheme). The strategy makes the asymmetric synthesis of biologically important phosphonate compounds more accessible.
已开发出烯酮的首例催化不对称磷迈克尔加成反应。在温和的反应条件下，可高产率（高达99%）且对映选择性优异（对映体过量值为93 - 99%；见图）地获得γ-氧代膦酸酯。该策略使具有生物学重要性的膦酸酯化合物的不对称合成更易实现。
