Georgia Prevention Institute, Department of Medicine, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA.
Department of Medicine, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA.
Nutrients. 2020 Apr 2;12(4):981. doi: 10.3390/nu12040981.
Sphingolipid metabolism plays a critical role in cell growth regulation, lipid regulation, neurodevelopment, type 2 diabetes, and cancer. Animal experiments suggest that vitamin D may be involved in sphingolipid metabolism regulation. In this study, we tested the hypothesis that vitamin D supplementation would alter circulating long-chain ceramides and related metabolites involved in sphingolipid metabolism in humans. We carried out a post-hoc analysis of a previously conducted randomized, placebo-controlled clinical trial in 70 overweight/obese African-Americans, who were randomly assigned into four groups of 600, 2000, 4000 IU/day of vitamin D supplements or placebo for 16 weeks. The metabolites were measured in 64 subjects (aged 26.0 ± 9.4 years, 17% male). Serum levels of -stearoyl-sphingosine (d18:1/18:0) (C18Cer) and stearoyl sphingomyelin (d18:1/18:0) (C18SM) were significantly increased after vitamin D supplementation (s < 0.05) in a dose-response fashion. The effects of 600, 2000, and 4000 IU/day vitamin D supplementation on C18Cer were 0.44 ( = 0.049), 0.52 ( = 0.016), and 0.58 ( = 0.008), respectively. The effects of three dosages on C18SM were 0.30 ( = 0.222), 0.61 ( = 0.009), and 0.68 ( = 0.004), respectively. This was accompanied by the significant correlations between serum 25-hydroxyvitamin D [25(OH)D] concentration and those two metabolites (s < 0.05). Vitamin D supplementations increase serum levels of C18Cer and C18SM in a dose-response fashion among overweight/obese African Americans.
鞘脂代谢在细胞生长调节、脂质调节、神经发育、2 型糖尿病和癌症中起着关键作用。动物实验表明，维生素 D 可能参与鞘脂代谢调节。在这项研究中，我们检验了这样一个假设，即维生素 D 补充会改变循环长链神经酰胺和参与鞘脂代谢的相关代谢物。我们对之前进行的一项随机、安慰剂对照临床试验进行了事后分析，该试验纳入了 70 名超重/肥胖的非裔美国人，他们被随机分为四组，分别接受 600、2000、4000 IU/天的维生素 D 补充剂或安慰剂治疗，为期 16 周。在 64 名受试者（年龄 26.0±9.4 岁，17%为男性）中测量了代谢物。维生素 D 补充后，-硬脂酰鞘氨醇（d18:1/18:0）（C18Cer）和硬脂酰鞘磷脂（d18:1/18:0）（C18SM）的血清水平呈剂量依赖性显著增加（s<0.05）。600、2000 和 4000 IU/天维生素 D 补充对 C18Cer 的影响分别为 0.44（=0.049）、0.52（=0.016）和 0.58（=0.008）。三种剂量对 C18SM 的影响分别为 0.30（=0.222）、0.61（=0.009）和 0.68（=0.004）。这伴随着血清 25-羟维生素 D [25（OH）D]浓度与这两种代谢物之间的显著相关性（s<0.05）。维生素 D 补充以剂量反应的方式增加超重/肥胖非裔美国人血清中 C18Cer 和 C18SM 的水平。
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