平均首次通过时间基因组重排距离。

A mean first passage time genome rearrangement distance.

机构信息

Centre for Research in Mathematics and Data Science, Western Sydney University, Sydney, Australia.

Centre for the Analysis of Time Series, London School of Economics, London, UK.

出版信息

J Math Biol. 2020 May;80(6):1971-1992. doi: 10.1007/s00285-020-01487-w. Epub 2020 Apr 6.

DOI:10.1007/s00285-020-01487-w

PMID:32253463

Abstract

This paper introduces a new way to define a genome rearrangement distance, using the concept of mean first passage time from probability theory. Crucially, this distance provides a genuine metric on genome space. We develop the theory and introduce a link to a graph-based zeta function. The approach is very general and can be applied to a wide variety of group-theoretic models of genome evolution.

摘要

本文提出了一种新的定义基因组重排距离的方法，使用概率论中的平均首通时间的概念。关键的是，该距离为基因组空间提供了真正的度量。我们发展了该理论并引入了一个与基于图的zeta 函数的联系。该方法非常通用，可以应用于广泛的基因组进化的群论模型。