Department of Radiology, Jikei University School of Medicine, 3-25-8 Nishi-Shimbashi, Minato-ku, Tokyo, 105-8461, Japan.
Department of Radiology, Daisan Hospital, The Jikei University School of Medicine, Tokyo, Japan.
Jpn J Radiol. 2020 Aug;38(8):746-752. doi: 10.1007/s11604-020-00968-8. Epub 2020 Apr 6.
The purpose of this study was to present the novel MRI findings of palatine gland lesion-associated IgG4-related disease (PGL-IgG4-RD) and to compare the imaging features with those in normal individuals.
We retrospectively evaluated the MRI scans of 12 patients with PGL-IgG4-RD and 12 control individuals. We measured the thickness of the palatal regions and calculated the T2-weighted signal intensity ratio of palatal regions to cerebral white matter (HWR) and compared them between the PGL-IgG4-RD and control groups.
In univariate analysis, the HWR of the palatal regions on T2-weighted imaging was smaller in the PGL-IgG4-RD group than in the control group (average = 1.2 vs. 1.9, p < 0.001). The palate thickness in patients with PGL-IgG4-RD was significantly greater than that in controls (average = 12 vs 6 mm, p < 0.001). The cut-off value of the between-group palate thickness on coronal MRI was 8 mm.
The thickening of the palatal regions seen with low signal intensity on T2-weighted imaging may be a characteristic imaging feature of PGL-IgG4-RD. Such findings will be useful for the timely diagnosis and subsequent treatment planning of IgG4-RDHP.
本研究旨在提出腭腺体病变相关 IgG4 相关疾病（PGL-IgG4-RD）的新型 MRI 表现，并将其影像学特征与正常个体进行比较。
我们回顾性评估了 12 例 PGL-IgG4-RD 患者和 12 名对照个体的 MRI 扫描结果。我们测量了腭部区域的厚度，并计算了腭部区域相对于脑白质的 T2 加权信号强度比（HWR），并在 PGL-IgG4-RD 组和对照组之间进行了比较。
在单变量分析中，PGL-IgG4-RD 组的 T2 加权成像上腭部区域的 HWR 小于对照组（平均 1.2 比 1.9，p<0.001）。PGL-IgG4-RD 患者的腭部厚度明显大于对照组（平均 12 比 6 毫米，p<0.001）。冠状位 MRI 上两组间腭部厚度的截断值为 8 毫米。
T2 加权成像上低信号强度的腭部区域增厚可能是 PGL-IgG4-RD 的特征性影像学表现。这些发现将有助于 IgG4-RDHP 的及时诊断和后续治疗计划。
