Clinical Medical College, Yangzhou University, Yangzhou, 225009, Jiangsu Province, China.
Department of Clinical Nutrition, Northern Jiangsu People's Hospital, Yangzhou, 225001, Jiangsu Province, China.
Biol Trace Elem Res. 2021 Jan;199(1):70-75. doi: 10.1007/s12011-020-02135-6. Epub 2020 Apr 6.
China has eliminated iodine deficiency disorders since 2011 via the implementation of universal salt iodisation. Following this, a new revised salt iodisation policy was introduced to reduce iodine content in table salt. Since maternal iodine deficiency can lead to cognitive impairment and cretinism in infants, the aim of our study was to assess if the iodine status of pregnant women and neonates was affected by the introduction of new salt iodisation policy. The medical records of the pregnant women and their neonates in the Northern Jiangsu People's Hospital, Yangzhou, Jiangsu Province, China, between January 2018 and May 2018 were reviewed and obtained. Our study included 374 mother-and-newborn pairs. Mean age of the participants was 28 ± 4 years. TSH, FT3 and FT4 of the participants remained within the reference range. The prevalence of thyroid dysfunction was 4.3%. The overall mean neonatal TSH, birth weight and prevalence of low birth weight (LBW) was 2.56 ± 1.59 mIU/L, 3348 ± 465 g and 2.4%, respectively. The prevalence of neonatal TSH values > 5 mIU/L was 8.3%, which suggested the emergence of mild iodine deficiency (i.e. 3.0-19.9%) in our province. In conclusion, although our study reported an improvement of iodine status to mild iodine deficiency in 2017, our pregnant women remained to be iodine deficient. We recommended an ongoing monitoring of iodine status and advocate for the routine iodine supplementation together with iodised salt in Chinese pregnant women.
中国自 2011 年实施普遍食盐碘化以来,已消除碘缺乏病。在此之后,推出了新的修订食盐碘化政策,以降低食盐中的碘含量。由于孕妇碘缺乏会导致婴儿认知障碍和克汀病,因此我们的研究旨在评估新的食盐碘化政策的实施是否会影响孕妇和新生儿的碘状况。我们回顾了 2018 年 1 月至 5 月期间江苏省扬州市苏北人民医院的孕妇及其新生儿的病历记录,共纳入 374 对母婴。参与者的平均年龄为 28 ± 4 岁。参与者的 TSH、FT3 和 FT4 仍在参考范围内。甲状腺功能障碍的患病率为 4.3%。新生儿 TSH、出生体重和低出生体重(LBW)的总体发生率分别为 2.56 ± 1.59 mIU/L、3348 ± 465 g 和 2.4%。新生儿 TSH 值>5 mIU/L 的患病率为 8.3%,这表明我省已出现轻度碘缺乏(即 3.0-19.9%)。总之,尽管我们的研究报告 2017 年碘状况有所改善,但孕妇仍存在碘缺乏。我们建议对碘状况进行持续监测,并提倡对中国孕妇进行常规碘补充和食用碘盐。