Zhou Hang, Lu Yiming, Luo Jianying, Pan Binyu, Zhao Qihua, Chen Min, Ma Zheng Feei
Northern Jiangsu People's Hospital Affiliated to Yangzhou University, Yangzhou, 225009, Jiangsu Province, China.
Department of Clinical Nutrition, Northern Jiangsu People's Hospital, Yangzhou, 225001, Jiangsu Province, China.
Sci Rep. 2025 Jan 7;15(1):1098. doi: 10.1038/s41598-024-80852-x.
Iron deficiency is prevalent among pregnant women because of the increased maternal iron requirements. Uncorrected maternal iron deficiency can lead to adverse neurodevelopmental outcomes in neonates. Therefore, the aim of this study was to assess serum ferritin concentration and prevalence of iron deficiency among pregnant women in Jiangsu, China. Within a cohort study, pregnant women were followed up from 2nd trimester of pregnancy until their labour. They were assessed for iron status in 2nd and 3rd trimesters using serum ferritin. In addition, neonatal APGAR score and birth weight were assessed in order to determine if maternal iron deficiency was associated with these neonatal outcomes. A total of 1688 pregnant women were followed up until their labour. The mean age of participants was 29 ± 4 years and 54.0% of them were multigravidas. Mean serum ferritin concentration in 2nd trimester was significantly higher than 3rd trimester (59.9 vs. 22.2 ng/mL) (P < 0.001). The prevalence of iron deficiency using serum ferritin concentration cut-off of < 15 ng/mL in 2nd and 3rd trimesters was 11.9% and 37.4%, respectively (P < 0.05). Maternal iron deficiency as assessed by serum ferritin concentration in 2nd and 3rd trimesters of pregnancy was not associated with neonatal outcomes (all P > 0.05). Our study reported that increased prevalence of maternal iron deficiency in 3rd trimester, suggesting that screening and supplementation of at-risk pregnancies can be used as a preventive strategy to tackle the issue. Consideration should be given to ensure adequate maternal iron status through pregnancy.
由于孕妇对铁的需求量增加，缺铁在孕妇中很普遍。未纠正的孕妇缺铁会导致新生儿出现不良神经发育结局。因此，本研究的目的是评估中国江苏省孕妇的血清铁蛋白浓度和缺铁患病率。在一项队列研究中，孕妇从妊娠中期开始随访直至分娩。在妊娠中期和晚期使用血清铁蛋白评估她们的铁状态。此外，评估新生儿阿氏评分和出生体重，以确定孕妇缺铁是否与这些新生儿结局相关。共有1688名孕妇随访至分娩。参与者的平均年龄为29±4岁，其中54.0%为经产妇。妊娠中期的平均血清铁蛋白浓度显著高于晚期（59.9对22.2 ng/mL）（P<0.001）。妊娠中期和晚期使用血清铁蛋白浓度临界值<15 ng/mL时的缺铁患病率分别为11.9%和37.4%（P<0.05）。妊娠中期和晚期通过血清铁蛋白浓度评估的孕妇缺铁与新生儿结局无关（所有P>0.05）。我们的研究报告称，妊娠晚期孕妇缺铁患病率增加，这表明对高危妊娠进行筛查和补充可以作为解决该问题的预防策略。应考虑在整个孕期确保孕妇有足够的铁状态。
