Zhang Simin, Chen Haobin, Zhang Guohua, Kong Xueping, Yin Shengyan, Li Bao, Wu Lixin
State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, Changchun, 130012, China.
J Mater Chem B. 2018 Jan 14;6(2):241-248. doi: 10.1039/c7tb02743e. Epub 2017 Dec 6.
A uniform ultra-small (<10 nm) nanosized dendritic composite was reported for combined photothermal-chemotherapy, wherein a giant ring-like polymolybdate cluster was introduced for the first time as a photothermal therapeutic agent. The giant polyoxometalate cluster possesses strong absorption characteristics in the near infrared region, whereas it has never been applied for biomaterials due to its sensitivity towards environment and structural instability under physiological conditions. Herein, a cationic dendron bearing triethylene glycol monomethyl ether terminal groups was used to cover a giant polyanionic cluster Mo surface through a simple electrostatic interaction. Arising from their assembly, the formed core-shell supramolecular composite that has uniform size, precise chemical composition and definite molecular weight not only exhibited mono-dispersion and low cytotoxicity, but also imparted anticancer drug loading and thermoresponsive properties, thus leading to NIR-controlled drug release. When irradiated with an 808 nm NIR laser, the formed complex had significant in vivo photothermal-chemotherapeutic effects on tumor tissue, which makes it a promising material for applications in nanomedicine.
据报道，一种用于光热化疗联合治疗的均匀超小（<10纳米）纳米级树枝状复合材料，其中首次引入了一种巨大的环状聚钼酸盐簇作为光热治疗剂。这种巨大的多金属氧酸盐簇在近红外区域具有很强的吸收特性，然而由于其对环境敏感且在生理条件下结构不稳定，从未被应用于生物材料。在此，一种带有三甘醇单甲醚端基的阳离子树枝状分子通过简单的静电相互作用覆盖在巨大的聚阴离子簇Mo表面。通过它们的组装，形成的具有均匀尺寸、精确化学组成和确定分子量的核壳超分子复合材料不仅表现出单分散性和低细胞毒性，还赋予了抗癌药物负载和热响应特性，从而实现近红外控制的药物释放。当用808纳米近红外激光照射时，形成的复合物对肿瘤组织具有显著的体内光热化疗效果，这使其成为纳米医学应用中有前景的材料。
