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核心技术专利：CN118964589B侵权必究
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用于抗肿瘤和抗菌应用的基于多金属氧酸盐的纳米复合材料。

Polyoxometalate-based nanocomposites for antitumor and antibacterial applications.

作者信息

Chang Dening, Li Yanda, Chen Yuxuan, Wang Xiaojing, Zang Dejin, Liu Teng

机构信息

Institute of Materia Medica, Shandong First Medical University & Shandong Academy of Medical Sciences Jinan 250117 PR China

出版信息

Nanoscale Adv. 2022 Aug 17;4(18):3689-3706. doi: 10.1039/d2na00391k. eCollection 2022 Sep 13.

DOI:10.1039/d2na00391k
PMID:36133327
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9470027/
Abstract

Polyoxometalates (POMs), as emerging inorganic metal oxides, have been shown to have significant biological activity and great medicinal value. Nowadays, biologically active POM-based organic-inorganic hybrid materials have become the next generation of antibacterial and anticancer drugs because of their customizable molecular structures related to their highly enhanced antitumor activity and reduced toxicity to healthy cells. In this review, the current developed strategies with POM-based materials for the purpose of antibacterial and anticancer activities from different action principles inducing cell death and hyperpolarization, cell plasma membrane destruction, interference with bacterial respiratory chain and inhibiting bacterial growth are overviewed. Moreover, specific interactions between POM-based materials and biomolecules are highlighted for a better understanding of their antibacterial and anticancer mechanisms. POMs have great promise as next-generation antibacterial and anticancer drugs, and this review will provide a valuable systematic reference for the further development of POM-based nanomaterials.

摘要

多金属氧酸盐（POMs）作为新兴的无机金属氧化物，已被证明具有显著的生物活性和巨大的药用价值。如今，具有生物活性的基于POM的有机-无机杂化材料因其可定制的分子结构、高度增强的抗肿瘤活性以及对健康细胞毒性的降低，已成为下一代抗菌和抗癌药物。在这篇综述中，概述了目前基于POM的材料为实现抗菌和抗癌活性而采用的不同作用原理所开发的策略，这些原理包括诱导细胞死亡和超极化、破坏细胞质膜、干扰细菌呼吸链以及抑制细菌生长。此外，强调了基于POM的材料与生物分子之间的特定相互作用，以便更好地理解它们的抗菌和抗癌机制。POMs作为下一代抗菌和抗癌药物具有很大的潜力，这篇综述将为基于POM的纳米材料的进一步发展提供有价值的系统参考。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/14d5/9470027/0980b6fd32e4/d2na00391k-p6.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/14d5/9470027/c96d1e8a23bf/d2na00391k-f1.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/14d5/9470027/0980b6fd32e4/d2na00391k-p6.jpg

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[3]
Novel monodisperse FePt nanocomposites for T2-weighted magnetic resonance imaging: biomedical theranostics applications.

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[4]
Magnetic and near-infrared-II fluorescence Au-Gd nanoclusters for imaging-guided sensitization of tumor radiotherapy.

Nanoscale Adv. 2022-3-2

[5]
Metallodrugs in cancer nanomedicine.

Chem Soc Rev. 2022-4-4

[6]
Thermoresponsive and Self-Healing Hydrogel Based on Chitosan Derivatives and Polyoxometalate as an Antibacterial Coating.

Biomacromolecules. 2022-3-14

[7]
NMR Relaxivities of Paramagnetic Lanthanide-Containing Polyoxometalates.

Molecules. 2021-12-10

[8]
A supramolecular complex based on a Gd-containing polyoxometalate and food-borne peptide for MRI/CT imaging and NIR-triggered photothermal therapy.

Dalton Trans. 2021-6-15

[9]
Bacterial hyperpolarization modulated by polyoxometalates for solutions of antibiotic resistance.

J Inorg Biochem. 2021-7

[10]
Hybrid Polyoxometalate Salt Adhesion by Butyltin Functionalization.

ACS Appl Mater Interfaces. 2021-4-28

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