Simnett J, Walton J, Oates C
Anat Rec. 1977 Feb;187(2):273-9. doi: 10.1002/ar.1091870212.
Small fragments of kidney tissue were grafted into the right lung (Xenopus laevis) and the left lung was subsequently removed. This stimulated compensatory hyperplasia (increased mitotic rate) in alveolar tissue of the right lung and in the kidney graft. This suggests that the stimulus to compensatory hyperplasia is location-specific rather than tissue- or organ-specific. After implantation into the lung the kidney grafts are revascularized by the surrounding pulmonary supply. Damage or functional impairment of an organ usually produces a localized increase in the rate of blood flow and we therefore propose that this may lead to an increased rate of cell division in one of two ways: by permitting an increased functional capacity in the tissue concerned, or by causing a more rapid local clearance of mitotic control factors.
将小块肾组织移植到右肺（非洲爪蟾）中，随后切除左肺。这刺激了右肺肺泡组织和肾移植组织中的代偿性增生（有丝分裂率增加）。这表明代偿性增生的刺激是位置特异性的，而非组织或器官特异性的。植入肺后，肾移植组织通过周围的肺供血实现血管再生。器官的损伤或功能损害通常会使局部血流速率增加，因此我们认为这可能通过以下两种方式之一导致细胞分裂速率增加：通过增加相关组织的功能能力，或通过使有丝分裂控制因子在局部更快清除。
