Sun Pengfei, Wang Xiaoxiao, Wang Gaina, Deng Weixing, Shen Qingming, Jiang Rongcui, Wang Wenjun, Fan Quli, Huang Wei
Key Laboratory for Organic Electronics and Information Displays & Jiangsu Key Laboratory for Biosensors, Institute of Advanced Materials (IAM), Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM), Nanjing University of Posts & Telecommunications, 9 Wenyuan Road, Nanjing 210023, China.
J Mater Chem B. 2018 May 28;6(20):3395-3403. doi: 10.1039/c8tb00845k. Epub 2018 May 16.
Phototherapy has great promise for precise cancer diagnosis and effective therapy, but the development of one multifunctional nanoplatform for synergistic photodynamic therapy (PDT) and photothermal therapy (PTT) at a single excitation wavelength remains a challenge. In this work, a perylene diimide zwitterionic polymer PDS-PDI was synthesized via atom transfer radical polymerization (ATRP). This polymer was designed for photoacoustic imaging (PAI) guided synergistic PDT and PTT with single 660 nm near-infrared (NIR) light irradiation. The prepared PDS-PDI polymer presents high photothermal conversion efficiency (η≈ 40%) and efficient singlet oxygen quantum yield (Φ≈ 16.7%) under 660 nm laser irradiation. Polymer PDS-PDI also acts as a contrast agent for PAI, offering real-time monitoring in tumor sites. Additionally, in vitro and in vivo assays indicate that polymer PDS-PDI has good biocompatibility and effective tumor destruction ability under 660 nm laser irradiation. In brief, polymer PDS-PDI prepared in this study could be applied as a dual-mode phototherapeutic agent under single laser irradiation.
光疗在精确癌症诊断和有效治疗方面具有巨大潜力，但开发一种在单一激发波长下用于协同光动力疗法（PDT）和光热疗法（PTT）的多功能纳米平台仍然是一个挑战。在这项工作中，通过原子转移自由基聚合（ATRP）合成了一种苝二酰亚胺两性离子聚合物PDS-PDI。该聚合物设计用于在660 nm近红外（NIR）单光照射下进行光声成像（PAI）引导的协同PDT和PTT。制备的PDS-PDI聚合物在660 nm激光照射下具有高光热转换效率（η≈40%）和高效单线态氧量子产率（Φ≈16.7%）。聚合物PDS-PDI还可作为PAI的造影剂，在肿瘤部位进行实时监测。此外，体外和体内试验表明，聚合物PDS-PDI在660 nm激光照射下具有良好的生物相容性和有效的肿瘤破坏能力。简而言之，本研究制备的聚合物PDS-PDI可作为单激光照射下的双模光疗剂。
