Department of Pharmaceutics, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, Shandong 250012, China.
Shandong Provincial Qianfoshan Hospital, the First Hospital Affiliated with Shandong First Medical University, Jinan, Shandong 250014, China.
J Colloid Interface Sci. 2021 Jul 15;594:493-501. doi: 10.1016/j.jcis.2021.03.050. Epub 2021 Mar 17.
Theranostic nanoplatforms integrating simultaneously photodynamic therapy (PDT) and photothermal therapy (PTT) exhibit intrinsic advantages in tumor therapy due to distinct mechanisms of action. However, it is challenging to achieve PDT and PTT under single near-infrared (NIR) laser irradiation with a nanoplatform utilizing conventional organic photodynamic agent and inorganic photothermal agent owing to the difference in inherent excitation wavelengths. Particularly, the single NIR light (660 nm)-triggered PTT and PDT nanoplatform, constructed from chlorin e6 (Ce6) and copper sulfide (CuS) nanoparticles (NPs), has never been reported. Herein, we, for the first time, designed and established a dual-modal phototherapeutic nanoplatform that achieved both PTT and PDT under single NIR laser (660 nm) irradiation for Ce6 and CuS NPs with the strategy of core-shell structured CuS@Carbon integrated with Ce6. Introducing of carbon shell not only endows small CuS NPs with excellent tumor accumulation, but also significantly strengthens the photothermal performance of CuS NPs, realizing efficient photothermal performance under 660 nm laser irradiation. Moreover, Ce6 in carbon shell endowed the nanoplatform with photodynamic effect under 660 nm laser irradiation. The as-prepared Ce6/CuS@Carbon nanoplatform thus achieved dual-modal phototherapy under single NIR laser irradiation, significantly inhibiting tumor growth with minimal adverse effects and superior biosafety.
治疗性纳米平台同时整合光动力疗法（PDT）和光热疗法（PTT），由于其作用机制不同，在肿瘤治疗中具有内在优势。然而，由于传统有机光动力剂和无机光热剂固有激发波长的差异，利用单一近红外（NIR）激光辐照来实现 PDT 和 PTT 具有挑战性。特别是，从未报道过由氯卟啉（Ce6）和硫化铜（CuS）纳米颗粒（NPs）组成的单一 NIR 光（660nm）触发的 PTT 和 PDT 纳米平台。在此，我们首次设计并建立了一种双重模式光疗纳米平台，通过核壳结构的 CuS@Carbon 与 Ce6 集成的策略，在单一 NIR 激光（660nm）辐照下实现了 Ce6 和 CuS NPs 的 PTT 和 PDT。碳壳的引入不仅赋予了小尺寸的 CuS NPs 优异的肿瘤积累能力，而且显著增强了 CuS NPs 的光热性能，实现了在 660nm 激光照射下的高效光热性能。此外，碳壳中的 Ce6 赋予了纳米平台在 660nm 激光照射下的光动力效应。因此，所制备的 Ce6/CuS@Carbon 纳米平台在单一 NIR 激光照射下实现了双重模式光疗，具有最小的不良反应和优异的生物安全性，显著抑制了肿瘤生长。
