Qie Xingwang, Zan Minghui, Miao Peng, Li Li, Chang Zhimin, Ge Mingfeng, Gui Ping, Tang Yuguo, Dong Wen-Fei
CAS Key Laboratory of Bio-Medical Diagnostics, Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences, Suzhou 215163, P. R. China.
J Mater Chem B. 2018 Jun 7;6(21):3549-3554. doi: 10.1039/c8tb00193f. Epub 2018 May 18.
Carbon nanodots (CDs) are novel forms of zero-dimensional carbonaceous nanomaterials, which have attracted the attention of researchers. Long wavelength emission decreases the interference of auto-fluorescence of tissue and can also penetrate more deeply. However, it is still a challenge to develop red emissive CDs. In this work, nitrogen, sulfur co-doped CDs are synthesized with red light emission through one-step solvothermal treatment. The as-synthesized CDs exhibit excellent properties such as high chemical stability, good biocompatibility, excellent photoluminescence properties, good water solubility, and low toxicity, and also show high sensitivity and selectivity towards Fe sensing. The detection limit is as low as 17.3 nM. In addition, the CDs are successfully utilized for monitoring Fe in living cells, which demonstrates their promising applicability in bioimaging. Furthermore, a test paper based on the CQDs has been prepared. This developed nanosensor can detect Fe visually and sensitively without any further steps which will make a great contribution to the development of ion sensors.
碳纳米点（CDs）是零维碳质纳米材料的新型形式，已引起研究人员的关注。长波长发射可减少组织自发荧光的干扰，并且还能穿透得更深。然而，开发红色发光的碳纳米点仍然是一项挑战。在这项工作中，通过一步溶剂热法合成了具有红色发光的氮、硫共掺杂碳纳米点。所合成的碳纳米点表现出优异的性能，如高化学稳定性、良好的生物相容性、出色的光致发光性能、良好的水溶性和低毒性，并且对铁传感表现出高灵敏度和选择性。检测限低至17.3 nM。此外，碳纳米点已成功用于监测活细胞中的铁，这证明了它们在生物成像中具有广阔的应用前景。此外，还制备了基于碳量子点的试纸。这种开发的纳米传感器无需任何进一步的步骤即可直观、灵敏地检测铁，这将为离子传感器的发展做出巨大贡献。
