Zhai Yue, Bai Xue, Zhu Jinyang, Sun Xueke, Pan Gencai, Dong Biao, Xu Lin, Xu Wen, Zhang Shuang, Song Hongwei
State Key Laboratory of Integrated Optoelectronics, College of Electronic Science and Engineering, Jilin University, 2699 Qianjin Street, Changchun 130012, China.
J Mater Chem B. 2018 Jun 7;6(21):3579-3585. doi: 10.1039/c8tb00117k. Epub 2018 May 21.
Drug release systems with fluorescence detection have emerged as a potential application for the biological area of diagnosis and therapy. Carbon dots (CDs) are a promising fluorescence probe for application in a drug release system due to their excellent biocompatibility, low toxicity, chemical inertness, and non-blinking fluorescence emission. Herein, we developed a composite nanocarrier based on fluorescent CDs and polyvinylpyrrolidone (PVP) through an electrospinning technology. The as-prepared PVP/CD-ketoprofen (PVP/CD-KET) composite nanofiber presents bright blue-light fluorescence with a photoluminescence quantum yield (QY) of 65.7% and was utilized for loading a water-insoluble drug and moreover for monitoring the drug release process. In vitro tests indicate that the photoluminescence emission intensity of the CDs and the cumulative amount of KET released from the PVP/CD-KET composite nanofiber gradually increase with the release time. Furthermore, the emission intensity of the CDs as a function of the cumulative released amount of KET can be summarized by a power function. The correlation between the emission intensity of CDs and drug release amount can be potentially used to monitor the drug release process.
具有荧光检测功能的药物释放系统已成为生物诊断和治疗领域的一种潜在应用。碳点（CDs）因其优异的生物相容性、低毒性、化学惰性和无闪烁荧光发射，是一种有前景的用于药物释放系统的荧光探针。在此，我们通过静电纺丝技术开发了一种基于荧光碳点和聚乙烯吡咯烷酮（PVP）的复合纳米载体。所制备的PVP/CD-酮洛芬（PVP/CD-KET）复合纳米纤维呈现出明亮的蓝光荧光，光致发光量子产率（QY）为65.7%，用于负载水不溶性药物并监测药物释放过程。体外试验表明，碳点的光致发光发射强度以及从PVP/CD-KET复合纳米纤维中释放的酮洛芬累积量随释放时间逐渐增加。此外，碳点的发射强度作为酮洛芬累积释放量的函数可以用幂函数来概括。碳点发射强度与药物释放量之间的相关性可潜在地用于监测药物释放过程。
